The nodes of Ranvier have clustered Na+ and K+ channels necessary for rapid and efficient
axonal action potential conduction. However, detailed mechanisms of channel clustering …

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an inflammatory
neuropathy, classically characterised by a slowly progressive onset and symmetrical …

At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …

Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and
astrocytes constitute macroglia. This review deals with the recent progress related to the …

In the axons of cultured hippocampal neurons, actin forms various structures, including
bundles, patches (involved in the preservation of neuronal polarity), and a recently reported …

The spectrin-based membrane skeleton of the humble mammalian erythrocyte has provided
biologists with a set of interacting proteins with diverse roles in organization and survival of …

Injury to the central nervous system (CNS) results in oligodendrocyte cell death and
progressive demyelination. Demyelinated axons undergo considerable physiological …

Chronic inflammatory demyelination polyneuropathy is a heterogeneous and treatable
immune-mediated disorder that lacks biomarkers to support diagnosis. Recent evidence …

Efficient and rapid propagation of action potentials in myelinated axons depends on the
molecular specialization of the nodes of Ranvier. The nodal region is organized into several …

Traumatic brain injury (TBI) evokes widespread/diffuse axonal injury (TAI) significantly
contributing to its morbidity and mortality. While classic theories suggest that traumatically …