The adrenal glands are paired endocrine organs that produce steroid hormones and
catecholamines required for life. Adrenocortical carcinoma (ACC) is a rare and often fatal …

The role of Heat Shock Proteins (HSPs) is a “double-edged sword” with regards to tumors.
The location and interactions of HSPs determine their pro-or antitumor activity. The present …

Adrenocortical carcinoma is a heterogeneous and aggressive cancer that originates from
steroidogenic cells within the adrenal cortex. In this study, we have assessed for the …

Adrenocortical carcinoma (ACC) is a rare, heterogenous and highly malignant disease.
Management of ACC is dependent on disease stage with complete surgical resection as the …

Background The response of advanced adrenocortical carcinoma (ACC) to current
chemotherapies is unsatisfactory and a limited rate of response to immunotherapy was …

The chaperone system (CS) of an organism is composed of molecular chaperones,
chaperone co-factors, co-chaperones, and chaperone receptors and interactors. It is present …

Primary aldosteronism is the most common cause of secondary hypertension. The first-line
treatment adrenalectomy resects adrenal nodules and adjacent normal tissue, limiting …

The adrenal gland provides an important function by integrating neuronal, immune,
vascular, metabolic and endocrine signals under a common organ capsule. It is the central …

The heat shock protein 90 inhibitor, luminespib, has demonstrated potent preclinical activity
against numerous cancers. However, clinical translation has been impeded by dose-limiting …

Molecular chaperones, many of which are heat shock proteins (Hsps), are components of
the chaperoning system and when defective can cause disease, the chaperonopathies …