Multiple sclerosis: molecular mechanisms and therapeutic opportunities

D Miljković, I Spasojević - Antioxidants & redox signaling, 2013 - liebertpub.com
The pathophysiology of multiple sclerosis (MS) involves several components: redox,
inflammatory/autoimmune, vascular, and neurodegenerative. All of them are supported by …

Epstein-Barr virus in systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis—association and causation

A Lossius, JN Johansen, Ø Torkildsen, F Vartdal… - Viruses, 2012 - mdpi.com
Epidemiological data suggest that the Epstein-Barr virus (EBV) is associated with several
autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and …

Safety and efficacy of ofatumumab in relapsing-remitting multiple sclerosis: a phase 2 study

PS Sorensen, S Lisby, R Grove, F Derosier… - Neurology, 2014 - AAN Enterprises
Objectives: We present the first study to explore safety and efficacy of the human CD20
monoclonal antibody ofatumumab in relapsing-remitting multiple sclerosis (RRMS) …

Cumulative roles for Epstein-Barr virus, human endogenous retroviruses, and human herpes virus-6 in driving an inflammatory cascade underlying MS pathogenesis

UC Meier, RC Cipian, A Karimi, R Ramasamy… - Frontiers in …, 2021 - frontiersin.org
Roles for viral infections and aberrant immune responses in driving localized
neuroinflammation and neurodegeneration in multiple sclerosis (MS) are the focus of …

Vitamin-D deficiency as a potential environmental risk factor in multiple sclerosis, schizophrenia, and autism

E Kočovská, F Gaughran, A Krivoy, UC Meier - Frontiers in psychiatry, 2017 - frontiersin.org
In this short review, we want to summarize the current findings on the role of vitamin-D in
multiple sclerosis (MS), schizophrenia, and autism. Many studies have highlighted …

B cells from patients with multiple sclerosis induce cell death via apoptosis in neurons in vitro

RP Lisak, L Nedelkoska, JA Benjamins… - Journal of …, 2017 - Elsevier
B cells mediate multiple sclerosis (MS) pathogenesis by mechanisms unrelated to
immunoglobulin (Ig). We reported that supernatants (Sup) from cultured B cells from blood of …

Ocrelizumab Impairs the Phenotype and Function of Memory CD8+ T Cells: A 1-Year Longitudinal Study in Patients With Multiple Sclerosis

A Mathias, V Pantazou, S Perriot… - Neurology …, 2023 - AAN Enterprises
Background and Objective Depleting CD20+ B cells is the primary mechanism by which
ocrelizumab (OCRE) is efficient in persons with multiple sclerosis (pwMS). However, the …

Environmental factors and their regulation of immunity in multiple sclerosis

MW Koch, LM Metz, SM Agrawal, VW Yong - Journal of the neurological …, 2013 - Elsevier
Epidemiological and clinical studies have shown that environmental factors such as
infections, smoking and vitamin D are associated with the risk of developing multiple …

Activation of MSRV-type endogenous retroviruses during infectious mononucleosis and Epstein-Barr virus latency: the missing link with multiple sclerosis?

G Mameli, G Madeddu, A Mei, E Uleri, L Poddighe… - PLoS …, 2013 - journals.plos.org
The etiology of multiple sclerosis (MS) is still unclear. The immuno-pathogenic phenomena
leading to neurodegeneration are thought to be triggered by environmental (viral?) factors …

Immunity orchestrates a bridge in gut-brain axis of neurodegenerative diseases

Y Cheng, C Chen, F Zhang - Ageing Research Reviews, 2023 - Elsevier
Neurodegenerative diseases, in particular for Alzheimer's disease (AD), Parkinson's disease
(PD) and Multiple sclerosis (MS), are a category of diseases with progressive loss of …