Multiple sclerosis: molecular mechanisms and therapeutic opportunities
D Miljković, I Spasojević - Antioxidants & redox signaling, 2013 - liebertpub.com
The pathophysiology of multiple sclerosis (MS) involves several components: redox,
inflammatory/autoimmune, vascular, and neurodegenerative. All of them are supported by …
inflammatory/autoimmune, vascular, and neurodegenerative. All of them are supported by …
Epstein-Barr virus in systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis—association and causation
A Lossius, JN Johansen, Ø Torkildsen, F Vartdal… - Viruses, 2012 - mdpi.com
Epidemiological data suggest that the Epstein-Barr virus (EBV) is associated with several
autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and …
autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and …
Safety and efficacy of ofatumumab in relapsing-remitting multiple sclerosis: a phase 2 study
PS Sorensen, S Lisby, R Grove, F Derosier… - Neurology, 2014 - AAN Enterprises
Objectives: We present the first study to explore safety and efficacy of the human CD20
monoclonal antibody ofatumumab in relapsing-remitting multiple sclerosis (RRMS) …
monoclonal antibody ofatumumab in relapsing-remitting multiple sclerosis (RRMS) …
Cumulative roles for Epstein-Barr virus, human endogenous retroviruses, and human herpes virus-6 in driving an inflammatory cascade underlying MS pathogenesis
Roles for viral infections and aberrant immune responses in driving localized
neuroinflammation and neurodegeneration in multiple sclerosis (MS) are the focus of …
neuroinflammation and neurodegeneration in multiple sclerosis (MS) are the focus of …
Vitamin-D deficiency as a potential environmental risk factor in multiple sclerosis, schizophrenia, and autism
In this short review, we want to summarize the current findings on the role of vitamin-D in
multiple sclerosis (MS), schizophrenia, and autism. Many studies have highlighted …
multiple sclerosis (MS), schizophrenia, and autism. Many studies have highlighted …
B cells from patients with multiple sclerosis induce cell death via apoptosis in neurons in vitro
RP Lisak, L Nedelkoska, JA Benjamins… - Journal of …, 2017 - Elsevier
B cells mediate multiple sclerosis (MS) pathogenesis by mechanisms unrelated to
immunoglobulin (Ig). We reported that supernatants (Sup) from cultured B cells from blood of …
immunoglobulin (Ig). We reported that supernatants (Sup) from cultured B cells from blood of …
Ocrelizumab Impairs the Phenotype and Function of Memory CD8+ T Cells: A 1-Year Longitudinal Study in Patients With Multiple Sclerosis
A Mathias, V Pantazou, S Perriot… - Neurology …, 2023 - AAN Enterprises
Background and Objective Depleting CD20+ B cells is the primary mechanism by which
ocrelizumab (OCRE) is efficient in persons with multiple sclerosis (pwMS). However, the …
ocrelizumab (OCRE) is efficient in persons with multiple sclerosis (pwMS). However, the …
Environmental factors and their regulation of immunity in multiple sclerosis
Epidemiological and clinical studies have shown that environmental factors such as
infections, smoking and vitamin D are associated with the risk of developing multiple …
infections, smoking and vitamin D are associated with the risk of developing multiple …
Activation of MSRV-type endogenous retroviruses during infectious mononucleosis and Epstein-Barr virus latency: the missing link with multiple sclerosis?
G Mameli, G Madeddu, A Mei, E Uleri, L Poddighe… - PLoS …, 2013 - journals.plos.org
The etiology of multiple sclerosis (MS) is still unclear. The immuno-pathogenic phenomena
leading to neurodegeneration are thought to be triggered by environmental (viral?) factors …
leading to neurodegeneration are thought to be triggered by environmental (viral?) factors …
Immunity orchestrates a bridge in gut-brain axis of neurodegenerative diseases
Y Cheng, C Chen, F Zhang - Ageing Research Reviews, 2023 - Elsevier
Neurodegenerative diseases, in particular for Alzheimer's disease (AD), Parkinson's disease
(PD) and Multiple sclerosis (MS), are a category of diseases with progressive loss of …
(PD) and Multiple sclerosis (MS), are a category of diseases with progressive loss of …