Abstract Purpose of Review The bone is able to adapt its structure to mechanical signals via
the bone remodeling process governed by mechanosensitive osteocytes. With aging, an …

Abstract Space sojourns are challenging for life. The ability of the human body to adapt to
these extreme conditions has been noted since the beginning of human space travel …

Disuse and aging are known risk factors associated with low bone mass and quality
deterioration, resulting in increased fracture risk. Indeed, current and emerging evidence …

The weightless environment during spaceflight induces site-specific bone loss. The 30-day
Bion-M1 mission offered a unique opportunity to characterize the skeletal changes after …

Osteocytes make up 90–95% of the cellular content of bone and form a rich dendritic
network with a vastly greater surface area than either osteoblasts or osteoclasts. Osteocytes …

Micro-computed tomography (micro-CT)—a version of X-ray CT operating at high spatial
resolution—has had a considerable success for the investigation of trabecular bone micro …

Osteocytes are believed to be the primary agents of mechanosensing in bone. Due to this
important role in the structure–function relationship of bone, osteocytes and the spaces they …

Abstract Purpose of Review Osteocytes directly modify the bone surrounding the expansive
lacunar-canalicular system (LCS) through both resorption and deposition. The existence of …

Bone is not only a dynamic living tissue, but also a composite material with a complex
hierarchical structure, responsible for bone's remarkable functionality. However, advanced …

Assessing the role of osteocyte lacunae and the ways in which they communicate with one
another is important for determining the function and viability of bone tissue. Osteocytes are …