Targeted proteomics technique has emerged as a powerful protein quantification tool in
systems biology, biomedical research, and increasing for clinical applications. The most …

Data‐independent acquisition (DIA) offers several advantages over data‐dependent
acquisition (DDA) schemes for characterizing complex protein digests analyzed by LC …

There is a need to better understand and handle the'dark matter'of proteomics—the vast
diversity of post-translational and chemical modifications that are unaccounted in a typical …

As a result of recent improvements in mass spectrometry (MS), there is increased interest in
data-independent acquisition (DIA) strategies in which all peptides are systematically …

Elucidating how and to what extent lipid metabolism is remodeled under changing
conditions is essential for understanding cellular physiology. Here, we analyzed proteome …

Molecular mechanisms underlying health and disease function at least in part based on the
flexibility and fine-tuning afforded by protein isoforms and post-translational modifications …

Proteomics provides molecular bases of biology and disease, and liquid chromatography–
tandem mass spectrometry (LC–MS/MS) is a platform widely used for bottom-up proteomics …

SuperQuant is a quantitative proteomics data processing approach that uses
complementary fragment ions to identify multiple coisolated peptides in tandem mass …

Proteomics has become an attractive science in the postgenomic era, given its capacity to
identify up to thousands of molecules in a single, complex sample and quantify them in an …

The impact of mixture spectra deconvolution on the performance of four popular de novo
sequencing programs was tested using artificially constructed mixture spectra as well as …