Carbon monoxide (CO) is continuously produced in mammalian cells during the
degradation of heme. It is a stable gaseous molecule that reacts selectively with transition …

Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

Protoporphyrin IX iron complex (heme) is an important cofactor for oxygen transfer, oxygen
storage, oxygen activation, and electron transfer when bound to the heme proteins …

Heme is an essential cofactor and signaling molecule required for virtually all aerobic life.
However, excess heme is cytotoxic. Therefore, heme must be safely transported and …

Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …

Heme is an essential cofactor for many human proteins as well as the primary transporter of
oxygen in blood. Recent studies have also established heme as a signaling molecule …

Heme, as a hydrophobic iron-containing organic ring, is lipid soluble and can interact with
biological membranes. The very same properties of heme that nature exploits to support life …

Heme is essential for the survival of virtually all living systems─ from bacteria, fungi, and
yeast, through plants to animals. No eukaryote has been identified that can survive without …

Heme is an iron-containing cofactor essential for multiple cellular processes and
fundamental activities such as oxygen transport. To better understand the means by which …

ATP synthesis and thermogenesis are two critical outputs of mitochondrial respiration. How
these outputs are regulated to balance the cellular requirement for energy and heat is …