Background The management of articular cartilage defects presents many clinical
challenges due to its avascular, aneural and alymphatic nature. Bone marrow stimulation …

A significant number of clinical trials have been undertaken to explore the use of
mesenchymal stem cells (MSCs) for the treatment of several diseases such as Crohn's …

Caused by the DNA monkeypox virus belonging to the orthopoxvirus genus and transmitted
between animals and humans and from human to human, monkeypox disease results in …

The regeneration of focal articular cartilage defects is complicated by the reduced quality of
the repair tissue and the potential development of perifocal osteoarthritis (OA). Biomaterial …

Increasing evidence indicates that decellularized extracellular matrices (dECMs) derived
from cartilage tissues (T-dECMs) or chondrocytes/stem cells (C-dECMs) can support …

Abstract Background Concentrated growth factors (CGFs) are the latest generation of
platelet concentrates. The objective of developing CGF is to increase therapeutic efficacy …

Cartilage regeneration is dependent on cellular-extracellular matrix (ECM) interactions.
Natural ECM plays a role in mechanical and chemical cell signaling and promotes stem cell …

Adult stem cells, also termed as somatic stem cells, are undifferentiated cells, detected
among differentiated cells in a tissue or an organ. Adult stem cells can differentiate toward …

Recombinant adeno-associated viral (rAAV) vectors are clinically adapted gene transfer
vectors for direct human cartilage regenerative medicine. Their appropriate use in patients is …

This review explores the regenerative potential of key progenitor cell types and therapeutic
strategies to improve healing of complex fractures and bone defects. We define, summarize …