Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

The first paper on “inflammaging” published in 2001 paved the way for a unifying theory on
how and why aging turns out to be the main risk factor for the development of the most …

Obesity is one of the major risk factors for the development of both impaired glucose
tolerance (IGT, or prediabetes) and type 2 diabetes (T2D), and its prevalence worldwide …

Atherosclerosis is one of the main complications of diabetes involving multiple causative
factors. Dysfunction of the vascular endothelium is a hallmark of most conditions that are …

Diabetes results from the inability of pancreatic islets to maintain blood glucose
concentrations within a normal physiological range. Clinical features are usually not …

Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and
atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ …

Obesity is a major risk factor for type 2 diabetes and a trigger of chronic and systemic
inflammation. Recent evidence suggests that an increased burden of senescent cells (SCs) …

Type 2 diabetes mellitus (T2DM) is a complex multifactorial disease causing the
development of a large range of cardiovascular (CV) complications. Lifestyle changes and …

The endothelium plays a pivotal role in maintaining vascular health. Obesity is a global
epidemic that has seen dramatic increases in both adult and pediatric populations. Obesity …

Oxidative stress (OxS) is the cause and the consequence of metabolic syndrome (MetS), the
incidence and economic burden of which is increasing each year. OxS triggers the …