The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …

Inequalities in health outcomes impose substantial human and economic costs on all
societies—and the relation between early adversity and lifelong well-being presents a rich …

Worldwide 300 million children and adults are affected by asthma. The development of
asthma is influenced by environmental and other exogenous factors synergizing with …

Executive summary Asthma is responsible for considerable global morbidity and health-care
costs. Substantial progress was made against key outcomes such as hospital admissions …

Throughout the past century, we have seen the emergence of a large number of
multifactorial diseases, including inflammatory, autoimmune, metabolic, neoplastic and …

Interspecies transmissions of viruses between animals and humans may result in
unpredictable pathogenic potential and new transmissible diseases. This mechanism has …

The microbiota plays a central role in human health and disease by shaping immune
development, immune responses and metabolism, and by protecting from invading …

The composition of the human gut microbiome matures within the first years of life. It has
been hypothesized that microbial compositions in this period can cause immune …

Exposures to adverse environments, both psychosocial and physicochemical, are prevalent
and consequential across a broad range of childhood populations. Such adversity …

Asthma prevalence has increased in epidemic proportions with urbanization, but growing up
on traditional farms offers protection even today. The asthma-protective effect of farms …