First identified in the early 1980s as retroviral oncogenes, the Raf proteins have been the
objects of intense research. The discoveries 10 years later that the Raf family members (Raf …

The interplay of mathematical modelling with experiments is one of the central elements in
systems biology. The aim of reverse engineering is to infer, analyse and understand …

Mathematical equations are fundamental to modeling biological networks, but as networks
get large and revisions frequent, it becomes difficult to manage equations directly or to …

Chemical reactions occur in energy, environmental, biological, and many other natural
systems, and the inference of the reaction networks is essential to understand and design …

As modeling becomes a more widespread practice in the life sciences and biomedical
sciences, researchers need reliable tools to calibrate models against ever more complex …

Interplay between the signaling pathways of the intracellular second messengers, cAMP and
Ca2+, has vital consequences for numerous essential physiological processes. Although …

Mechanistic mathematical modeling of biochemical reaction networks using ordinary
differential equation (ODE) models has improved our understanding of small-and medium …

The advancements in “omics”(proteomics, genomics, lipidomics, and metabolomics)
technologies have yielded large inventories of genes, transcripts, proteins, and metabolites …

The kinase mammalian target of rapamycin (mTOR) exists in two multiprotein complexes
(mTORC1 and mTORC2) and is a central regulator of growth and metabolism. Insulin …

Developing mechanistic models has become an integral aspect of systems biology, as has
the need to differentiate between alternative models. Parameterizing mathematical models …