Enhancer elements function as the logic gates of the genetic regulatory circuitry. One of their
most important functions is the integration of extracellular signals with intracellular cell fate …

The intestine is a vital organ responsible for nutrient absorption, bile and waste excretion,
and a major site of host immunity. In order to keep up with daily demands, the intestine has …

INTRODUCTION One fundamental property of the immune system is its ability to develop
memory of previous encounters, resulting in enhanced responsiveness to subsequent …

As the sequencing of healthy and disease genomes becomes more commonplace, detailed
annotation provides interpretation for individual variation responsible for normal and …

Organs are composed of diverse cell types that traverse transient states during
organogenesis. To interrogate this diversity during human development, we generate a …

Heart development is exquisitely sensitive to the precise temporal regulation of thousands of
genes that govern developmental decisions during differentiation. However, we currently …

Replicating Lgr5+ stem cells and quiescent Bmi1+ cells behave as intestinal stem cells
(ISCs) in vivo. Disrupting Lgr5+ ISCs triggers epithelial renewal from Bmi1+ cells, from …

Engineering clinically relevant cells in vitro holds promise for regenerative medicine, but
most protocols fail to faithfully recapitulate target cell properties. To address this, we …

Transcriptional enhancers are the primary determinants of tissue-specific gene expression.
Although the majority of our current knowledge of enhancer elements comes from detailed …

BMP/SMAD signaling is a crucial regulator of intestinal differentiation,,–. However, the
molecular underpinnings of the BMP pathway in this context are unknown. Here, we …