Radiotherapy is used in the treatment of approximately 50% of all malignancies including
gastrointestinal cancers. Radiation can be given prior to surgery (neoadjuvant radiotherapy) …

There has been mounting evidence of a causal role for telomere dysfunction in a number of
degenerative disorders. Their manifestations encompass common disease states such as …

Purpose: One of the main limitations to anticancer radiotherapy lies in irreversible damage
to healthy tissues located within the radiation field.“FLASH” irradiation at very high dose-rate …

Most human somatic cells can undergo only a limited number of population doublings in
vitro. This exhaustion of proliferative potential, called senescence, can be triggered when …

The Sir2 histone deacetylase functions as a chromatin silencer to regulate recombination,
genomic stability, and aging in budding yeast. Seven mammalian Sir2 homologs have been …

Myriad genetic and epigenetic alterations are required to drive normal cells toward
malignant transformation. These somatic events commandeer many signaling pathways that …

Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the
processes that trigger cellular responses to telomere dysfunction, we crossed mTR−/− G6 …

Stem cells are controlled, in part, by genetic pathways frequently dysregulated during
human tumorigenesis. Either stimulation of Wnt/β-catenin signalling or overexpression of …

Aging can be defined as progressive functional decline and increasing mortality over time.
Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates …

Telomerase is an attractive cancer target as it appears to be required in essentially all
tumours for immortalization of a subset of cells, including cancer stem cells. Moreover …