Zebrafish have several advantages compared to other vertebrate models used in modeling
human diseases, particularly for large-scale genetic mutant and therapeutic compound …

Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

A major contribution to the genome variability among individuals comes from deletions and
duplications—collectively termed copy number variations (CNVs)—which alter the diploid …

Recent genome-sequencing studies in human neurodevelopmental and psychiatric
disorders have uncovered mutations in many chromatin regulators. These human genetic …

Kleefstra syndrome, caused by haploinsufficiency of euchromatin histone methyltransferase
1 (EHMT1), is characterized by intellectual disability (ID), autism spectrum disorder (ASD) …

Methylation of histone H3 lysine 4 (H3K4me) is an intricately regulated posttranslational
modification, which is broadly associated with enhancers and promoters of actively …

Background DYRK1A maps to the Down syndrome critical region at 21q22. Mutations in this
kinase-encoding gene have been reported to cause microcephaly associated with either …

Myopia is the most common cause of visual impairment worldwide. Genetic and
environmental factors contribute to the development of myopia. Studies on the molecular …

Enhancers are a class of regulatory elements essential for precise spatio-temporal control of
gene expression during development and in terminally differentiated cells. This review …