Preclinical activities of epigallocatechin gallate in signaling pathways in cancer
Epigallocatechin gallate (EGCG) is the main bioactive component of catechins
predominantly present in various types of tea. EGCG is well known for a wide spectrum of …
predominantly present in various types of tea. EGCG is well known for a wide spectrum of …
Advances in Mechanism Research on Polygonatum in Prevention and Treatment of Diabetes
S Liu, QJ Jia, YQ Peng, TH Feng, ST Hu… - Frontiers in …, 2022 - frontiersin.org
Diabetes mellitus is a fast-growing disease with a major influence on people's quality of life.
Oral hypoglycemic drugs and insulin are currently the main effective drugs in the treatment …
Oral hypoglycemic drugs and insulin are currently the main effective drugs in the treatment …
Formononetin ameliorates renal dysfunction, oxidative stress, inflammation, and apoptosis and upregulates Nrf2/HO-1 signaling in a rat model of gentamicin-induced …
Gentamicin (GEN) is a bactericidal aminoglycoside known to cause nephrotoxicity.
Formononetin (FN) is a potent flavonoid that exhibits numerous promising pharmacological …
Formononetin (FN) is a potent flavonoid that exhibits numerous promising pharmacological …
Protective effect of Polygonatum sibiricum polysaccharides on gentamicin-induced acute kidney injury in rats via inhibiting p38 MAPK/ATF2 pathway
C Han, T Sun, Y Liu, G Fan, W Zhang, C Liu - International journal of …, 2020 - Elsevier
The aim of this study was to investigate the protective effect of Polygonatum sibiricum
polysaccharides (PSP) on acute kidney injury (AKI) in rats. The AKI model was established …
polysaccharides (PSP) on acute kidney injury (AKI) in rats. The AKI model was established …
Potential nephroprotective phytochemicals: Mechanism and future prospects
Ethnopharmacological relevance Kidney disease (KD) is one of the serious health issues,
which causes worrisome morbidity and economic burden. Therapeutic strategies are …
which causes worrisome morbidity and economic burden. Therapeutic strategies are …
[PDF][PDF] Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1–7 Signals.
Cadmium (Cd) is a serious pollutant in the environment. Candesartan is an angiotensin II
(Ang II) receptor antagonist with promising diverse health benefits. The current study is …
(Ang II) receptor antagonist with promising diverse health benefits. The current study is …
Diosmin mitigates gentamicin-induced nephrotoxicity in rats: Insights on miR-21 and-155 expression, Nrf2/HO-1 and p38-MAPK/NF-κB pathways
Gentamicin (GNT) is the most frequently used aminoglycoside. However, its therapeutic
efficacy is limited due to nephrotoxicity. Thus, the potential anticipatory effect of Diosmin …
efficacy is limited due to nephrotoxicity. Thus, the potential anticipatory effect of Diosmin …
Targeting KEAP1/Nrf2, AKT, and PPAR-γ signals as a potential protective mechanism of diosmin against gentamicin-induced nephrotoxicity
Aim Gentamicin (GM) is an aminoglycoside antibiotic effectively used for severe/life-
threatening infections. However, the clinical application of GM is limited by nephrotoxic side …
threatening infections. However, the clinical application of GM is limited by nephrotoxic side …
Epigallocatechin gallate attenuates gentamicin-induced nephrotoxicity by suppressing apoptosis and ferroptosis
L Yue, YR Yang, WX Ma, HY Wang, QW Fan, YY Wang… - Molecules, 2022 - mdpi.com
Gentamicin (GEN) is a kind of aminoglycoside antibiotic with the adverse effect of
nephrotoxicity. Currently, no effective measures against the nephrotoxicity have been …
nephrotoxicity. Currently, no effective measures against the nephrotoxicity have been …
Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma
NS Younis, AMH Ghanim, S Saber - Scientific reports, 2019 - nature.com
Sorafenib (SO) is a multi-kinase inhibitor that targets upstream signals in the MAPK pathway.
Drug resistance and transient survival benefits are the main obstacles associated with SO …
Drug resistance and transient survival benefits are the main obstacles associated with SO …