Preclinical activities of epigallocatechin gallate in signaling pathways in cancer

M Sharifi-Rad, R Pezzani, M Redaelli, M Zorzan… - Molecules, 2020 - mdpi.com
Epigallocatechin gallate (EGCG) is the main bioactive component of catechins
predominantly present in various types of tea. EGCG is well known for a wide spectrum of …

Advances in Mechanism Research on Polygonatum in Prevention and Treatment of Diabetes

S Liu, QJ Jia, YQ Peng, TH Feng, ST Hu… - Frontiers in …, 2022 - frontiersin.org
Diabetes mellitus is a fast-growing disease with a major influence on people's quality of life.
Oral hypoglycemic drugs and insulin are currently the main effective drugs in the treatment …

Formononetin ameliorates renal dysfunction, oxidative stress, inflammation, and apoptosis and upregulates Nrf2/HO-1 signaling in a rat model of gentamicin-induced …

OY Althunibat, MH Abukhalil, SH Aladaileh… - Frontiers in …, 2022 - frontiersin.org
Gentamicin (GEN) is a bactericidal aminoglycoside known to cause nephrotoxicity.
Formononetin (FN) is a potent flavonoid that exhibits numerous promising pharmacological …

Protective effect of Polygonatum sibiricum polysaccharides on gentamicin-induced acute kidney injury in rats via inhibiting p38 MAPK/ATF2 pathway

C Han, T Sun, Y Liu, G Fan, W Zhang, C Liu - International journal of …, 2020 - Elsevier
The aim of this study was to investigate the protective effect of Polygonatum sibiricum
polysaccharides (PSP) on acute kidney injury (AKI) in rats. The AKI model was established …

Potential nephroprotective phytochemicals: Mechanism and future prospects

P Basist, B Parveen, S Zahiruddin, G Gautam… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Kidney disease (KD) is one of the serious health issues,
which causes worrisome morbidity and economic burden. Therapeutic strategies are …

[PDF][PDF] Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1–7 Signals.

EO Kamel, WM Gad-Elrab, MA Ahmed… - Biological Trace …, 2023 - academia.edu
Cadmium (Cd) is a serious pollutant in the environment. Candesartan is an angiotensin II
(Ang II) receptor antagonist with promising diverse health benefits. The current study is …

Diosmin mitigates gentamicin-induced nephrotoxicity in rats: Insights on miR-21 and-155 expression, Nrf2/HO-1 and p38-MAPK/NF-κB pathways

RI Nadeem, AS Aboutaleb, NS Younis, HI Ahmed - Toxics, 2023 - mdpi.com
Gentamicin (GNT) is the most frequently used aminoglycoside. However, its therapeutic
efficacy is limited due to nephrotoxicity. Thus, the potential anticipatory effect of Diosmin …

Targeting KEAP1/Nrf2, AKT, and PPAR-γ signals as a potential protective mechanism of diosmin against gentamicin-induced nephrotoxicity

FEM Ali, AM Sayed, AH El-Bahrawy, ZMM Omar… - Life Sciences, 2021 - Elsevier
Aim Gentamicin (GM) is an aminoglycoside antibiotic effectively used for severe/life-
threatening infections. However, the clinical application of GM is limited by nephrotoxic side …

Epigallocatechin gallate attenuates gentamicin-induced nephrotoxicity by suppressing apoptosis and ferroptosis

L Yue, YR Yang, WX Ma, HY Wang, QW Fan, YY Wang… - Molecules, 2022 - mdpi.com
Gentamicin (GEN) is a kind of aminoglycoside antibiotic with the adverse effect of
nephrotoxicity. Currently, no effective measures against the nephrotoxicity have been …

Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma

NS Younis, AMH Ghanim, S Saber - Scientific reports, 2019 - nature.com
Sorafenib (SO) is a multi-kinase inhibitor that targets upstream signals in the MAPK pathway.
Drug resistance and transient survival benefits are the main obstacles associated with SO …