Metabolons in plant primary and secondary metabolism

T Obata - Phytochemistry Reviews, 2019 - Springer
Metabolons are multi-enzyme protein complexes composed of enzymes catalyzing
sequential reactions in a metabolic pathway. Metabolons mediate substrate channeling …

[HTML][HTML] Heterologous production of Cannabis sativa-derived specialised metabolites of medicinal significance–Insights into engineering strategies

D Wiles, BK Shanbhag, M O'Brien, MS Doblin, A Bacic… - Phytochemistry, 2022 - Elsevier
Cannabis sativa L. has been known for at least 2000 years as a source of important,
medically significant specialised metabolites and several bio-active molecules have been …

Advances in heterologous biosynthesis of plant and fungal natural products by modular co-culture engineering

T Chen, Y Zhou, Y Lu, H Zhang - Biotechnology letters, 2019 - Springer
Heterologous biosynthesis has been long pursued as a viable approach for high efficiency
production of natural products with various industrial values. Conventional methods for …

[HTML][HTML] Transport engineering for improving the production and secretion of valuable alkaloids in Escherichia coli

Y Yamada, M Urui, H Oki, K Inoue, H Matsui… - Metabolic engineering …, 2021 - Elsevier
Microorganisms can be metabolically engineered to produce specialized plant metabolites.
However, these methods are limited by low productivity and intracellular accumulation of …

Characterization of the Pro101Gln mutation that enhances the catalytic performance of T. indicus NADH-dependent d-lactate dehydrogenase

J Liu, G Liu, X Han, F Tao, P Xu - Structure, 2023 - cell.com
NADH-dependent d-lactate dehydrogenases (d-LDH) are important for the industrial
production of d-lactic acid. Here, we identify and characterize an improved d-lactate …

Tyrosinase-based production of l-DOPA by Corynebacterium glutamicum

E Kurpejović, VF Wendisch… - Applied Microbiology and …, 2021 - Springer
An increase in the number of elderly people suffering from the symptoms of Parkinson's
disease is leading to an expansion in the market size of 3, 4-dihydroxyphenyl-l-alanine (l …

[HTML][HTML] De novo biosynthesis of diverse plant-derived styrylpyrones in Saccharomyces cerevisiae

Y Wu, MN Chen, S Li - Metabolic Engineering Communications, 2022 - Elsevier
Plant styrylpyrones exerting well-established neuroprotective properties have attracted
increasing attention in recent years. The ability to synthesize each individual styrylpyrone in …

Role of Engineered Microbes in Sustainable Agriculture

BM Enuh, P Aytar Çelik - Beneficial Microorganisms in Agriculture, 2022 - Springer
For a long time, agricultural output had been solely dependent on available environmental
resources, and increasing pressure on these natural resources to meet the needs of an …