Biological activities of 3,4,5‐trihydroxypiperidines and their N‐ and O‐derivatives

K Prichard, D Campkin, N O'brien… - Chemical Biology & …, 2018 - Wiley Online Library
3, 4, 5‐Trihydroxypiperidines belong to the family of 1, 5‐dideoxy‐1, 5‐iminosugar natural
products and are structural analogues of pentose monosaccharides in the pyranose form …

Reductive amination routes in the synthesis of piperidine iminosugars

F Clemente, C Matassini… - European Journal of …, 2020 - Wiley Online Library
The reductive amination (RA) reaction plays a pivotal role in the synthesis of new C–N
bonds, due to the availability of many different and low‐cost reagents and their operational …

Synthesis and pharmacological activities of xanthone derivatives as α-glucosidase inhibitors

Y Liu, L Zou, L Ma, WH Chen, B Wang, ZL Xu - Bioorganic & medicinal …, 2006 - Elsevier
Considerable interest has been attracted in xanthone and its derivatives because of their
large variety of pharmacological activities. In this project, a series of hydroxylxanthones and …

Synthesis of xanthone derivatives with extended π-systems as α-glucosidase inhibitors: Insight into the probable binding mode

Y Liu, L Ma, WH Chen, B Wang, ZL Xu - Bioorganic & medicinal chemistry, 2007 - Elsevier
A series of novel xanthone derivatives with extended π-systems, that is, benzoxanthones 2–
4, and their structurally perturbed analogs 5–9 have been designed and synthesized as α …

[PDF][PDF] Xanthenone-based hydrazones as potent α-glucosidase inhibitors: Synthesis, solid state self-assembly and in silico studies

SU Khan, A Ashraf, M Ashraf, M Rafiq… - Bioorganic …, 2019 - academia.edu
Xanthenone based hydrazone derivatives (5a–n) have been synthesized as potential α-
glucosidase inhibitors. All synthesized compounds (5a–n) are characterized by their FTIR …

Iminosugars spiro-linked with morpholine-fused 1, 2, 3-triazole: Synthesis, conformational analysis, glycosidase inhibitory activity, antifungal assay, and docking …

SR Chavan, KS Gavale, A Khan, R Joshi… - ACS …, 2017 - ACS Publications
Synthesis of iminosugars 1, 2, 3a, and 4a and N-alkyl (ethyl, butyl, hexyl, octyl, decyl, and
dodecyl) derivatives 3b–g and 4b–g spiro-linked with morpholine-fused 1, 2, 3-triazole is …

A New Route to Diverse 1-Azasugars from N-Boc-5-hydroxy-3-piperidene as a Common Building Block

H Ouchi, Y Mihara, H Takahata - The Journal of Organic …, 2005 - ACS Publications
A new general method for the synthesis of a variety of 1-azasugars with a nitrogen atom at
the anomeric position is described. The readily available chiral N-Boc-5-hydroxy-3 …

Selective sulfonylation of 4-C-hydroxymethyl-β-L-threo-pento-1, 4-furanose: Synthesis of bicyclic diazasugars

DD Dhavale, MM Matin - Tetrahedron, 2004 - Elsevier
Hydroxymethylation of α-d-xylo-pentodialdose using excess formaldehyde and sodium
hydroxide in THF–water (one pot aldol and crossed Cannizzaro reactions) followed by …

Inhibitors for bacterial cell-wall recycling

T Yamaguchi, B Blázquez, D Hesek… - ACS medicinal …, 2012 - ACS Publications
Gram-negative bacteria have evolved an elaborate process for the recycling of their cell
wall, which is initiated in the periplasmic space by the action of lytic transglycosylases. The …

Total synthesis of pachastrissamine (jaspine B) enantiomers from D-glucose

CV Ramana, AG Giri, SB Suryawanshi, RG Gonnade - Tetrahedron letters, 2007 - Elsevier
Synthesis of both enantiomers of pachastrissamine is described from a common chiral
template. The stereoselective construction of the central tetrahydrofuran units was based on …