Abstract P2Y receptors are G protein‐coupled receptors (GPCRs) that are activated by
adenine and uridine nucleotides and nucleotide sugars. There are eight subtypes of P2Y …

Cancer is a complex expression of an altered state of cellular differentiation associated with
severe clinical repercussions. The effort to characterize this pathological entity to understand …

Long considered merely a trophic and mechanical support to neurons, astrocytes have
progressively taken the center stage as their ability to react to acute and chronic …

P2 receptors for extracellular nucleotides are divided into two categories: the ion channel
receptors (P2X) and the G-protein-coupled receptors (P2Y). For the P2X receptors, signal …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

Mitogen-activated protein (MAP) kinase signaling cascades play important roles in
eukaryotic defense against various pathogens. Activation of the extracellular ATP (eATP) …

The development of the nervous system requires complex series of cellular programming
and intercellular communication events that lead from the early neural induction to the …

Macrophages comprise a phenotypically and functionally diverse group of hematopoietic
cells. Versatile macrophage subsets engage to ensure maintenance of tissue integrity. To …

The P2Y receptors are a widely expressed group of eight nucleotide-activated G protein-
coupled receptors (GPCRs). The P2Y 1 (ADP), P2Y 2 (ATP/UTP), P2Y 4 (UTP), P2Y 6 …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive
loss of memory and cognitive ability and is a serious cause of mortality. Many of the …