The knowns and unknowns of latent Mycobacterium tuberculosis infection

WH Boom, UE Schaible… - The Journal of clinical …, 2021 - Am Soc Clin Investig
Humans have been infected with Mycobacterium tuberculosis (Mtb) for thousands of years.
While tuberculosis (TB), one of the deadliest infectious diseases, is caused by uncontrolled …

To Sobol or not to Sobol? The effects of sampling schemes in systems biology applications

M Renardy, LR Joslyn, JA Millar, DE Kirschner - Mathematical biosciences, 2021 - Elsevier
Computational and mathematical models in biology rely heavily on the parameters that
characterize them. However, robust estimates for their values are typically elusive and thus a …

Neutrophil Dynamics Affect Mycobacterium tuberculosis Granuloma Outcomes and Dissemination

C Hult, JT Mattila, HP Gideon, JJ Linderman… - Frontiers in …, 2021 - frontiersin.org
Neutrophil infiltration into tuberculous granulomas is often associated with higher bacteria
loads and severe disease but the basis for this relationship is not well understood. To better …

Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens

M Budak, JM Cicchese, P Maiello… - PLOS Computational …, 2023 - journals.plos.org
Tuberculosis (TB) continues to be one of the deadliest infectious diseases in the world,
causing~ 1.5 million deaths every year. The World Health Organization initiated an End TB …

A virtual host model of Mycobacterium tuberculosis infection identifies early immune events as predictive of infection outcomes

LR Joslyn, JJ Linderman, DE Kirschner - Journal of theoretical biology, 2022 - Elsevier
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (Mtb), is one of the
world's deadliest infectious diseases and remains a significant global health burden. TB …

Development and analysis of multiscale models for tuberculosis: from molecules to populations

P Nanda, M Budak, CT Michael, K Krupinsky… - Predicting Pandemics in …, 2024 - Springer
Although infectious disease dynamics are often analyzed at the macroscale, increasing
numbers of drug-resistant infections highlight the importance of within-host modeling that …

Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions Within Mycobacterium tuberculosis Granulomas

JA Millar, JR Butler, S Evans, NL Grant… - Frontiers in …, 2021 - frontiersin.org
Tuberculosis (TB) is a worldwide health problem; successful interventions such as vaccines
and treatment require a 2better understanding of the immune response to infection with …

A multi-approach and multi-scale platform to model CD4+ T cells responding to infections

KY Wertheim, BL Puniya, A La Fleur… - PLoS computational …, 2021 - journals.plos.org
Immune responses rely on a complex adaptive system in which the body and infections
interact at multiple scales and in different compartments. We developed a modular model of …

Decoding immune kinetics: unveiling secrets using custom-built mathematical models

AM Smith - Nature Methods, 2024 - nature.com
Decoding immune kinetics: unveiling secrets using custom-built mathematical models |
Nature Methods Skip to main content Thank you for visiting nature.com. You are using a …

A brief overview of mathematical modeling of the within-host dynamics of Mycobacterium tuberculosis

D Chakraborty, S Batabyal… - Frontiers in Applied …, 2024 - frontiersin.org
Tuberculosis (TB), a disease caused by bacteria Mycobacterium tuberculosis (Mtb), remains
one of the major infectious diseases of humans with 10 million TB cases and 1.5 million …