The knowns and unknowns of latent Mycobacterium tuberculosis infection
WH Boom, UE Schaible… - The Journal of clinical …, 2021 - Am Soc Clin Investig
Humans have been infected with Mycobacterium tuberculosis (Mtb) for thousands of years.
While tuberculosis (TB), one of the deadliest infectious diseases, is caused by uncontrolled …
While tuberculosis (TB), one of the deadliest infectious diseases, is caused by uncontrolled …
To Sobol or not to Sobol? The effects of sampling schemes in systems biology applications
Computational and mathematical models in biology rely heavily on the parameters that
characterize them. However, robust estimates for their values are typically elusive and thus a …
characterize them. However, robust estimates for their values are typically elusive and thus a …
Neutrophil Dynamics Affect Mycobacterium tuberculosis Granuloma Outcomes and Dissemination
Neutrophil infiltration into tuberculous granulomas is often associated with higher bacteria
loads and severe disease but the basis for this relationship is not well understood. To better …
loads and severe disease but the basis for this relationship is not well understood. To better …
Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens
M Budak, JM Cicchese, P Maiello… - PLOS Computational …, 2023 - journals.plos.org
Tuberculosis (TB) continues to be one of the deadliest infectious diseases in the world,
causing~ 1.5 million deaths every year. The World Health Organization initiated an End TB …
causing~ 1.5 million deaths every year. The World Health Organization initiated an End TB …
A virtual host model of Mycobacterium tuberculosis infection identifies early immune events as predictive of infection outcomes
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (Mtb), is one of the
world's deadliest infectious diseases and remains a significant global health burden. TB …
world's deadliest infectious diseases and remains a significant global health burden. TB …
Development and analysis of multiscale models for tuberculosis: from molecules to populations
Although infectious disease dynamics are often analyzed at the macroscale, increasing
numbers of drug-resistant infections highlight the importance of within-host modeling that …
numbers of drug-resistant infections highlight the importance of within-host modeling that …
Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions Within Mycobacterium tuberculosis Granulomas
Tuberculosis (TB) is a worldwide health problem; successful interventions such as vaccines
and treatment require a 2better understanding of the immune response to infection with …
and treatment require a 2better understanding of the immune response to infection with …
A multi-approach and multi-scale platform to model CD4+ T cells responding to infections
KY Wertheim, BL Puniya, A La Fleur… - PLoS computational …, 2021 - journals.plos.org
Immune responses rely on a complex adaptive system in which the body and infections
interact at multiple scales and in different compartments. We developed a modular model of …
interact at multiple scales and in different compartments. We developed a modular model of …
Decoding immune kinetics: unveiling secrets using custom-built mathematical models
AM Smith - Nature Methods, 2024 - nature.com
Decoding immune kinetics: unveiling secrets using custom-built mathematical models |
Nature Methods Skip to main content Thank you for visiting nature.com. You are using a …
Nature Methods Skip to main content Thank you for visiting nature.com. You are using a …
A brief overview of mathematical modeling of the within-host dynamics of Mycobacterium tuberculosis
D Chakraborty, S Batabyal… - Frontiers in Applied …, 2024 - frontiersin.org
Tuberculosis (TB), a disease caused by bacteria Mycobacterium tuberculosis (Mtb), remains
one of the major infectious diseases of humans with 10 million TB cases and 1.5 million …
one of the major infectious diseases of humans with 10 million TB cases and 1.5 million …