Metallodrugs in cancer nanomedicine
Metal complexes are extensively used for cancer therapy. The multiple variables available
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …
Cisplatin: The first metal based anticancer drug
S Ghosh - Bioorganic chemistry, 2019 - Elsevier
Abstract Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential
and widely used drugs for the treatment of various solid cancers such as testicular, ovarian …
and widely used drugs for the treatment of various solid cancers such as testicular, ovarian …
The role of ligands in the chemical synthesis and applications of inorganic nanoparticles
A Heuer-Jungemann, N Feliu, I Bakaimi… - Chemical …, 2019 - ACS Publications
The design of nanoparticles is critical for their efficient use in many applications ranging from
biomedicine to sensing and energy. While shape and size are responsible for the properties …
biomedicine to sensing and energy. While shape and size are responsible for the properties …
[HTML][HTML] Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components
The utilization of nanomaterials in the biological and medical field is quickly progressing,
particularly in areas where traditional diagnostics and treatment approaches have limited …
particularly in areas where traditional diagnostics and treatment approaches have limited …
Gold nanoparticles in cancer treatment
K Sztandera, M Gorzkiewicz… - Molecular …, 2018 - ACS Publications
Colloidal gold has been studied for its potential application in medicine for centuries.
However, synthesis and evaluation of various gold nanoparticles have only recently been …
However, synthesis and evaluation of various gold nanoparticles have only recently been …
Stimuli-responsive therapeutic metallodrugs
The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …
metal-based drugs for several decades, whereas problems such as drug-resistance and …
DNA origami: scaffolds for creating higher order structures
DNA has become one of the most extensively used molecular building blocks for
engineering self-assembling materials. DNA origami is a technique that uses hundreds of …
engineering self-assembling materials. DNA origami is a technique that uses hundreds of …
The next generation of platinum drugs: targeted Pt (II) agents, nanoparticle delivery, and Pt (IV) prodrugs
TC Johnstone, K Suntharalingam, SJ Lippard - Chemical reviews, 2016 - ACS Publications
The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,
but new platinum agents have been very slow to enter the clinic. Recently, however, there …
but new platinum agents have been very slow to enter the clinic. Recently, however, there …
Mechanism of hard-nanomaterial clearance by the liver
KM Tsoi, SA MacParland, XZ Ma, VN Spetzler… - Nature materials, 2016 - nature.com
The liver and spleen are major biological barriers to translating nanomedicines because
they sequester the majority of administered nanomaterials and prevent delivery to diseased …
they sequester the majority of administered nanomaterials and prevent delivery to diseased …
Gold nanomaterials at work in biomedicine
Gold is a precious metal with a characteristic bright and beautiful hue known as the golden
yellow color.(1) As of 2012, a total of 174,100 tons of Au has been mined in human history …
yellow color.(1) As of 2012, a total of 174,100 tons of Au has been mined in human history …