Background Two objectives of the NIMH Research Domain Criteria (RDoC) initiative are to
identify (a) mechanisms that are common to multiple psychiatric disorders, and (b) …

Objective In this critical review, the authors appraise neuroimaging findings in bipolar
disorder in emotion-processing, emotion-regulation, and reward-processing neural circuitry …

Strakowski SM, Adler CM, Almeida J, Altshuler LL, Blumberg HP, Chang KD, DelBello MP,
Frangou S, McIntosh A, Phillips ML, Sussman JE, Townsend JD. The functional …

Distinguishing depression in bipolar disorder (BD) from unipolar depression (UD) solely
based on clinical clues is difficult, which has led to the exploration of promising neural …

From a neurobiological perspective there is no such thing as bipolar disorder. Rather, it is
almost certainly the case that many somewhat similar, but subtly different, pathological …

Background Bipolar disorder (BD) is a psychiatric disorder characterized by episodes of
depression and mania, associated with impaired emotion processing. Several functional …

Although it is now well documented that bipolar disorder (BD) often presents with cognitive
deficits and suboptimal social adjustment, the social cognitive profile of the illness …

Introduction: Bipolar disorder (BD) is a chronic psychiatric disorder marked by clinical and
pathophysiological heterogeneity. There is a high expectation that personalized approaches …

Mania, the diagnostic hallmark of bipolar disorder, is an episodic disturbance of mood,
sleep, behavior, and perception. Improved understanding of the neurobiology of mania is …

Growing evidence indicates that risk for bipolar disorder is characterized by elevated
activation in a fronto-striatal reward neural circuit involving the ventral striatum and …