Ulcerative colitis in adults: A review

B Gros, GG Kaplan - Jama, 2023 - jamanetwork.com
Importance Ulcerative colitis (UC) is a chronic inflammatory condition of the colon, with a
prevalence exceeding 400 per 100 000 in North America. Individuals with UC have a lower …

Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis

JS Lasa, PA Olivera, S Danese… - The Lancet …, 2022 - thelancet.com
Background There is a growing armamentarium for the treatment of moderate-to-severe
ulcerative colitis. We aimed to compare the relative efficacy and safety of biologics and small …

ECCO guidelines on therapeutics in ulcerative colitis: medical treatment

T Raine, S Bonovas, J Burisch… - Journal of Crohn's …, 2022 - academic.oup.com
Ulcerative colitis [UC] is a chronic inflammatory bowel disease [IBD] characterised by colonic
inflammation extending to a variable extent from the rectum. Care of the patient with UC …

Novel and emerging therapies for inflammatory bowel disease

B Al-Bawardy, R Shivashankar… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease are
chronic, relapsing and remitting disorders of intestinal inflammation with potential systemic …

[HTML][HTML] Randomized controlled trial: subcutaneous vs intravenous infliximab CT-P13 maintenance in inflammatory bowel disease

S Schreiber, S Ben-Horin, J Leszczyszyn, R Dudkowiak… - Gastroenterology, 2021 - Elsevier
Background & aims This study compared pharmacokinetics, symptomatic and endoscopic
efficacy, safety, and immunogenicity of a subcutaneous formulation of the infliximab …

Emerging treatments for inflammatory bowel disease

K Hazel, A O'Connor - Therapeutic advances in chronic …, 2020 - journals.sagepub.com
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), is characterized by chronic inflammation, a relapsing and remitting clinical course …

Efficacy and safety of subcutaneous vedolizumab in patients with moderately to severely active Crohn's disease: results from the VISIBLE 2 randomised trial

S Vermeire, G D'Haens, F Baert… - Journal of Crohn's …, 2022 - academic.oup.com
Abstract Background and Aims To report results from VISIBLE 2, a randomised, double-
blind, placebo-controlled, phase 3 trial evaluating a new subcutaneous [SC] vedolizumab …

An update on current pharmacotherapeutic options for the treatment of ulcerative colitis

F Ferretti, R Cannatelli, MC Monico, G Maconi… - Journal of Clinical …, 2022 - mdpi.com
The main goals of Ulcerative Colitis (UC) treatment are to both induce and maintain the
clinical and endoscopic remission of disease, reduce the incidence of complications such as …

Colorectal cancer in ulcerative colitis: mechanisms, surveillance and chemoprevention

W Li, T Zhao, D Wu, J Li, M Wang, Y Sun, S Hou - Current Oncology, 2022 - mdpi.com
Patients with ulcerative colitis (UC) are at a two-to three-fold increased risk of developing
colorectal cancer (CRC) than the general population based on population-based data. UC …

[HTML][HTML] Optimizing therapies using therapeutic drug monitoring: current strategies and future perspectives

PM Irving, KB Gecse - Gastroenterology, 2022 - Elsevier
Therapeutic drug monitoring (TDM) has emerged as a strategy for treatment optimization in
inflammatory bowel diseases to maximize benefit and to reach more stringent, objective end …