Apoptosis is a process of programmed cell death that serves as a major mechanism for the
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …

Rapid progress in deciphering the biological mechanism of Alzheimer's disease (AD) has
arisen from the application of molecular and cell biology to this complex disorder of the …

Studies of the molecular basis of Alzheimer's disease exemplify the increasingly blurred
distinction between basic and applied biomedical research. The four genes so far implicated …

Various mutations in the amyloid protein precursor and presenilin genes can lead to early
onset, autosomal Alzheimer's disease. A series of mis-sense mutations (with one exception) …

Oxidative balance is emerging as an important issue in understanding the pathogenesis of
Alzheimer's disease. Examination of Alzheimer's disease brain has demonstrated a great …

Through functional expression screening, we identified a gene, designated Humanin (HN)
cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by …

Presenilins play essential roles in memory formation, synaptic function, and neuronal
survival. Mutations in the Presenilin-1 (PSEN1) gene are the major cause of familial …

Apoptotic programmed cell death pathways are activated by a diverse array of cell extrinsic
and intrinsic signals, most of which are ultimately coupled to the activation of effector …

Abstract Presenilin-1 (PS1) is the major gene responsible for early-onset familial Alzheimer's
disease (FAD). To understand the normal function of PS1, we have generated a targeted …

Certain proteases are not merely degradative enzymes but are highly regulated signaling
molecules that control critical biological processes via specific limited proteolysis. Caspase …