Lipids are a complex and diverse group of molecules with crucial roles in many
physiological processes, as well as in the onset, progression, and maintenance of cancers …

Primary liver cancer (PLC) is the fourth most frequent cause of cancer-related death. The
high mortality rates arise from late diagnosis and the limited accuracy of diagnostic and …

Biopsy is the recommended standard for pathological diagnosis of liver carcinoma.
However, this method usually requires sectioning and staining, and well-trained pathologists …

Elevated de novo lipogenesis is considered to be a crucial factor in hepatocellular
carcinoma (HCC) development. Herein, we identify ubiquitin-specific protease 22 (USP22) …

Dysregulated metabolism is a hallmark of cancer, manifested through alterations in
metabolites. We performed metabolomic profiling on 138 matched clear cell renal cell …

Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. The lack of
effective biomarkers for the early detection of HCC results in unsatisfactory curative …

Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in
cancer remains elusive. Here, using integrative metabolomics and transcriptomics analyses …

Metabolomics is an emerging approach in a systems biology field. Due to continuous
development in advanced analytical techniques and in bioinformatics, metabolomics has …

Alterations of hepatic metabolism are critical to the development of liver disease. The
peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on …

肝癌是病死率最高的恶性肿瘤之一. 我国每年约有38.3 万人死于肝癌, 占全球肝癌死亡病例数的
51%, 严峻的形势给我国的社会和医疗带来了沉重的负担. 不断增加的科研经费投入为我国肝癌 …