RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression
S Rezatabar, A Karimian, V Rameshknia… - Journal of cellular …, 2019 - Wiley Online Library
Mitogen‐activated protein kinase (MAPK) signaling pathways organize a great constitution
network that regulates several physiological processes, like cell growth, differentiation, and …
network that regulates several physiological processes, like cell growth, differentiation, and …
Role of Merlin/NF2 inactivation in tumor biology
AM Petrilli, C Fernández-Valle - Oncogene, 2016 - nature.com
Abstract Merlin (Moesin-ezrin-radixin-like protein, also known as schwannomin) is a tumor
suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Loss of function …
suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Loss of function …
Proteogenomics connects somatic mutations to signalling in breast cancer
Somatic mutations have been extensively characterized in breast cancer, but the effects of
these genetic alterations on the proteomic landscape remain poorly understood. Here we …
these genetic alterations on the proteomic landscape remain poorly understood. Here we …
Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups
The rates and routes of lethal systemic spread in breast cancer are poorly understood owing
to a lack of molecularly characterized patient cohorts with long-term, detailed follow-up data …
to a lack of molecularly characterized patient cohorts with long-term, detailed follow-up data …
Activating ESR1 mutations in hormone-resistant metastatic breast cancer
Breast cancer is the most prevalent cancer in women, and over two-thirds of cases express
estrogen receptor-α (ER-α, encoded by ESR1). Through a prospective clinical sequencing …
estrogen receptor-α (ER-α, encoded by ESR1). Through a prospective clinical sequencing …
Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
The incidence of esophageal adenocarcinoma (EAC) has risen 600% over the last 30 years.
With a 5-year survival rate of∼ 15%, the identification of new therapeutic targets for EAC is …
With a 5-year survival rate of∼ 15%, the identification of new therapeutic targets for EAC is …
PAK signalling during the development and progression of cancer
M Radu, G Semenova, R Kosoff, J Chernoff - Nature reviews Cancer, 2014 - nature.com
Abstract p21-activated kinases (PAKs) are positioned at the nexus of several oncogenic
signalling pathways. Overexpression or mutational activation of PAK isoforms frequently …
signalling pathways. Overexpression or mutational activation of PAK isoforms frequently …
P21 activated kinase signaling in cancer
CK Rane, A Minden - Seminars in cancer biology, 2019 - Elsevier
Abstract The p21 Activated Kinases (PAKs) are a family of serine threonine kinases, that
consist of 6 members, PAKs 1–6, which are positioned at an intersection of multiple …
consist of 6 members, PAKs 1–6, which are positioned at an intersection of multiple …
DawnRank: discovering personalized driver genes in cancer
JP Hou, J Ma - Genome medicine, 2014 - Springer
Large-scale cancer genomic studies have revealed that the genetic heterogeneity of the
same type of cancer is greater than previously thought. A key question in cancer genomics is …
same type of cancer is greater than previously thought. A key question in cancer genomics is …
PAK signaling in cancer
DZ Ye, J Field - Cellular logistics, 2012 - Taylor & Francis
Transformation of a normal cell to a cancer cell is caused by mutations in genes that
regulate proliferation, apoptosis, and invasion. Small GTPases such as Ras, Rho, Rac and …
regulate proliferation, apoptosis, and invasion. Small GTPases such as Ras, Rho, Rac and …