Mitogen‐activated protein kinase (MAPK) signaling pathways organize a great constitution
network that regulates several physiological processes, like cell growth, differentiation, and …

Abstract Merlin (Moesin-ezrin-radixin-like protein, also known as schwannomin) is a tumor
suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Loss of function …

Somatic mutations have been extensively characterized in breast cancer, but the effects of
these genetic alterations on the proteomic landscape remain poorly understood. Here we …

The rates and routes of lethal systemic spread in breast cancer are poorly understood owing
to a lack of molecularly characterized patient cohorts with long-term, detailed follow-up data …

Breast cancer is the most prevalent cancer in women, and over two-thirds of cases express
estrogen receptor-α (ER-α, encoded by ESR1). Through a prospective clinical sequencing …

The incidence of esophageal adenocarcinoma (EAC) has risen 600% over the last 30 years.
With a 5-year survival rate of∼ 15%, the identification of new therapeutic targets for EAC is …

Abstract p21-activated kinases (PAKs) are positioned at the nexus of several oncogenic
signalling pathways. Overexpression or mutational activation of PAK isoforms frequently …

Abstract The p21 Activated Kinases (PAKs) are a family of serine threonine kinases, that
consist of 6 members, PAKs 1–6, which are positioned at an intersection of multiple …

Large-scale cancer genomic studies have revealed that the genetic heterogeneity of the
same type of cancer is greater than previously thought. A key question in cancer genomics is …

Transformation of a normal cell to a cancer cell is caused by mutations in genes that
regulate proliferation, apoptosis, and invasion. Small GTPases such as Ras, Rho, Rac and …