Transglutaminase regulation of cell function
RL Eckert, MT Kaartinen, M Nurminskaya… - Physiological …, 2014 - journals.physiology.org
Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding
functions that participate in regulation of cell fate in a wide range of cellular systems and are …
functions that participate in regulation of cell fate in a wide range of cellular systems and are …
Multifactorial skin barrier deficiency and atopic dermatitis: Essential topics to prevent the atopic march
G Egawa, K Kabashima - Journal of Allergy and Clinical Immunology, 2016 - Elsevier
Atopic dermatitis (AD) is the most common inflammatory skin disease in the industrialized
world and has multiple causes. Over the past decade, data from both experimental models …
world and has multiple causes. Over the past decade, data from both experimental models …
Barrier dysfunction in the skin allergy
G Egawa, K Kabashima - Allergology international, 2018 - jstage.jst.go.jp
abstract The skin is continuously exposed to external pathogens, and its barrier function is
critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one …
critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one …
Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer
JDA Sharpen, B Dolan, EEL Nyström… - Nature …, 2022 - nature.com
The colonic mucus layer is organized as a two-layered system providing a physical barrier
against pathogens and simultaneously harboring the commensal flora. The factors …
against pathogens and simultaneously harboring the commensal flora. The factors …
Deimination and peptidylarginine deiminases in skin physiology and diseases
MC Méchin, H Takahara, M Simon - International journal of molecular …, 2020 - mdpi.com
Deimination, also known as citrullination, corresponds to the conversion of the amino acid
arginine, within a peptide sequence, into the non-standard amino acid citrulline. This post …
arginine, within a peptide sequence, into the non-standard amino acid citrulline. This post …
Hyperglycemia induces skin barrier dysfunctions with impairment of epidermal integrity in non-wounded skin of type 1 diabetic mice
J Okano, H Kojima, M Katagi, T Nakagawa, Y Nakae… - PloS one, 2016 - journals.plos.org
Diabetes causes skin complications, including xerosis and foot ulcers. Ulcers complicated
by infections exacerbate skin conditions, and in severe cases, limb/toe amputations are …
by infections exacerbate skin conditions, and in severe cases, limb/toe amputations are …
Transglutaminases in autoimmune and inherited skin diseases: The phenomena of epitope spreading and functional compensation
S Kárpáti, M Sárdy, K Németh, B Mayer… - Experimental …, 2018 - Wiley Online Library
Transglutaminases (TG s) are structurally and functionally related enzymes that modify the
post‐translational structure and activity of proteins or peptides, and thus are able to turn on …
post‐translational structure and activity of proteins or peptides, and thus are able to turn on …
Transglutaminase 3: the involvement in epithelial differentiation and cancer
ES Chermnykh, EV Alpeeva, EA Vorotelyak - Cells, 2020 - mdpi.com
Transglutaminases (TGMs) contribute to the formation of rigid, insoluble macromolecular
complexes, which are essential for the epidermis and hair follicles to perform protective and …
complexes, which are essential for the epidermis and hair follicles to perform protective and …
Transglutaminase 2 mediates UV-induced skin inflammation by enhancing inflammatory cytokine production
UV irradiation elicits acute inflammation in the skin by increasing proinflammatory cytokine
production in keratinocytes. However, the downstream protein target (s) that link UV …
production in keratinocytes. However, the downstream protein target (s) that link UV …
Multiple defects of natural killer cells in cancer patients: anarchy, dysregulated systemic immunity, and immunosuppression in metastatic cancer
We have previously demonstrated that natural killer (NK) cells are the main immune
effectors that can mediate selection and differentiation of different cancer stem cells and …
effectors that can mediate selection and differentiation of different cancer stem cells and …