Transglutaminase regulation of cell function

RL Eckert, MT Kaartinen, M Nurminskaya… - Physiological …, 2014 - journals.physiology.org
Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding
functions that participate in regulation of cell fate in a wide range of cellular systems and are …

Multifactorial skin barrier deficiency and atopic dermatitis: Essential topics to prevent the atopic march

G Egawa, K Kabashima - Journal of Allergy and Clinical Immunology, 2016 - Elsevier
Atopic dermatitis (AD) is the most common inflammatory skin disease in the industrialized
world and has multiple causes. Over the past decade, data from both experimental models …

Barrier dysfunction in the skin allergy

G Egawa, K Kabashima - Allergology international, 2018 - jstage.jst.go.jp
abstract The skin is continuously exposed to external pathogens, and its barrier function is
critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one …

Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer

JDA Sharpen, B Dolan, EEL Nyström… - Nature …, 2022 - nature.com
The colonic mucus layer is organized as a two-layered system providing a physical barrier
against pathogens and simultaneously harboring the commensal flora. The factors …

Deimination and peptidylarginine deiminases in skin physiology and diseases

MC Méchin, H Takahara, M Simon - International journal of molecular …, 2020 - mdpi.com
Deimination, also known as citrullination, corresponds to the conversion of the amino acid
arginine, within a peptide sequence, into the non-standard amino acid citrulline. This post …

Hyperglycemia induces skin barrier dysfunctions with impairment of epidermal integrity in non-wounded skin of type 1 diabetic mice

J Okano, H Kojima, M Katagi, T Nakagawa, Y Nakae… - PloS one, 2016 - journals.plos.org
Diabetes causes skin complications, including xerosis and foot ulcers. Ulcers complicated
by infections exacerbate skin conditions, and in severe cases, limb/toe amputations are …

Transglutaminases in autoimmune and inherited skin diseases: The phenomena of epitope spreading and functional compensation

S Kárpáti, M Sárdy, K Németh, B Mayer… - Experimental …, 2018 - Wiley Online Library
Transglutaminases (TG s) are structurally and functionally related enzymes that modify the
post‐translational structure and activity of proteins or peptides, and thus are able to turn on …

Transglutaminase 3: the involvement in epithelial differentiation and cancer

ES Chermnykh, EV Alpeeva, EA Vorotelyak - Cells, 2020 - mdpi.com
Transglutaminases (TGMs) contribute to the formation of rigid, insoluble macromolecular
complexes, which are essential for the epidermis and hair follicles to perform protective and …

Transglutaminase 2 mediates UV-induced skin inflammation by enhancing inflammatory cytokine production

SJ Lee, KB Lee, YH Son, J Shin, JH Lee, HJ Kim… - Cell death & …, 2017 - nature.com
UV irradiation elicits acute inflammation in the skin by increasing proinflammatory cytokine
production in keratinocytes. However, the downstream protein target (s) that link UV …

Multiple defects of natural killer cells in cancer patients: anarchy, dysregulated systemic immunity, and immunosuppression in metastatic cancer

A Jewett, J Kos, K Kaur, TL Turnsek… - Critical Reviews™ in …, 2020 - dl.begellhouse.com
We have previously demonstrated that natural killer (NK) cells are the main immune
effectors that can mediate selection and differentiation of different cancer stem cells and …