Gene transfer has long been a compelling yet elusive therapeutic modality. First mainly
considered for rare inherited disorders, gene therapy may open treatment opportunities for …

Adeno-associated virus (AAV) vectors efficiently transduce various cell types and can
produce long-term expression of transgenes in vivo. Although AAV vector genomes can …

Recombinant adeno-associated virus vectors based on serotype 2 (rAAV2) can direct
transgene expression in the central nervous system (CNS), but it is not known how other …

Recombinant adeno-associated viral (rAAV) vectors based on serotype 2 are currently being
evaluated most extensively in animals and human clinical trials. rAAV vectors constructed …

Recombinant adeno-associated viral (AAV) vectors can transduce cells of the CNS, resulting
in long-term expression. AAV vector transduction varies depending on the serotype used …

Gene therapy can be broadly defined as the transfer of genetic material to cure a disease or
at least to improve the clinical status of a patient. One of the basic concepts of gene therapy …

Chimeric antigen receptor (CAR) T cell therapy has been successful in treating B cell
malignancies in clinical trials; however, fewer studies have evaluated CAR T cell therapy for …

Behaviors associated with monogamy, including pair-bond formation, are facilitated by the
neuropeptide vasopressin and are prevented by a vasopressin receptor [V1a receptor …

Klotho is a recently discovered antiaging gene. The objective of this study was to test the
hypothesis that klotho gene delivery attenuates the progression of spontaneous …

Recombinant adeno-associated virus (rAAV) vectors are promising human gene transfer
vectors, because they mediate long-term gene expression in vivo. The vector DNA form …