In this report, we developed a unified and standardized one-pot sequence that converts
pyridine derivatives into 1, 2-diazepines by inserting a nitrogen atom. This skeletal …

Recent advances in single-atom insertion reactions have opened up new synthetic
approaches for molecular diversification. Developing innovative strategies to directly …

Fluorinated quinolines and pyridines are prevalent pharmacophores, yet their synthesis is
often challenging. Herein, we demonstrate that dibromofluoromethane as …

The skeletal editing of azaarenes through insertion, deletion, or swapping of single atoms
has recently gained considerable momentum in chemical synthesis. Here, we describe a …

This Feature Article discusses recent advances in the development of cascade ring
expansion reactions for the synthesis of medium-sized rings and macrocycles. Cascade ring …

Despite the significant achievements in dearomatization and C–H functionalization of
arenes, the arene ring-opening remains a largely unmet challenge and is underdeveloped …

Given the prevalence of heterocyclic scaffolds in drug‐related molecules, converting these
highly modular heterocyclic scaffolds into structural diversified and dearomatized analogs is …

An electrooxidative reconstruction of the indole core under ambient conditions is reported,
resulting in the construction of tryptanthrins. This electrochemical strategy simplifies …

Comprehensive Summary A mild and practical method for synthesizing fluorinated quinoline
derivatives, which have a wide range of applications in pharmaceuticals, materials, and …

Carbon atom insertion into a cyclic framework is an attractive form of molecular editing since
it can modify the core skeleton of a molecule, allowing for controlled increases in molecular …