Small molecule based five-membered heterocycles: A view of liquid crystalline properties beyond the biological applications

SY Kotian, CD Mohan, AA Merlo, S Rangappa… - Journal of Molecular …, 2020 - Elsevier
Liquid crystal (LC) is an intermediate phase of matter with the physical attributes of liquid,
and a high-level of orientational order of solids. This property of LCs has been widely …

Crocetin imparts antiproliferative activity via inhibiting STAT3 signaling in hepatocellular carcinoma

CD Mohan, C Kim, KS Siveen, KA Manu… - IUBMB …, 2021 - Wiley Online Library
STAT3 is a key oncogenic transcription factor, often overactivated in several human cancers
including hepatocellular carcinoma (HCC). STAT3 modulates the expression of genes that …

Novel 1, 3, 4-oxadiazole induces anticancer activity by targeting NF-κB in hepatocellular carcinoma cells

CD Mohan, NC Anilkumar, S Rangappa… - Frontiers in …, 2018 - frontiersin.org
Aberrant activation of NF-κB is linked with the progression of human malignancies including
hepatocellular carcinoma (HCC), and blockade of NF-κB signaling could be a potential …

Insights into adopted synthetic approaches for 1, 2, 4-oxadiazoles: A review

R Kumar, RK Yadav, A Mazumder… - Synthetic …, 2023 - Taylor & Francis
A five-membered heterocyclic compound known as 1, 2, 4-oxadiazole has one oxygen, two
carbon, and two nitrogen atoms within a ring. Numerous studies have shown that 1, 2, 4 …

Brucein D modulates MAPK signaling cascade to exert multi-faceted anti-neoplastic actions against breast cancer cells

CD Mohan, YY Liew, YY Jung, S Rangappa… - Biochimie, 2021 - Elsevier
Breast cancer is a prominent type of malignancy among women with a high rate of mortality.
A number of previous studies have demonstrated the anticancer potential of brucein D (BD) …

[HTML][HTML] Nimbolide enhances the antitumor effect of docetaxel via abrogation of the NF-κB signaling pathway in prostate cancer preclinical models

J Zhang, YY Jung, CD Mohan, A Deivasigamani… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Prostate cancer is the second most frequent type of cancer that affects men. Docetaxel (DTX)
administration is the front-line therapy for patients with advanced prostate cancer and …

Co2(CO)8 as a Solid CO (g) Source for the Amino Carbonylation of (Hetero)aryl Halides with Highly Deactivated (Hetero)arylamines

S Cheruku, AM Sajith, Y Narayana… - The Journal of …, 2021 - ACS Publications
Carbonylation of (hetero) aryl iodides/bromides with highly deactivated 2-aminopyridines
using Pd–Co (CO) 4 bimetallic catalysis is accomplished. The use of Co2 (CO) 8 as a solid …

Euphorbiasteroid abrogates EGFR and Wnt/β-catenin signaling in non-small-cell lung cancer cells to impart anticancer activity

NY Kim, CD Mohan, A Chinnathambi, SA Alharbi… - Molecules, 2022 - mdpi.com
EGFR and Wnt/β-catenin signaling pathways play a prominent role in tumor progression in
various human cancers including non-small-cell lung carcinoma (NSCLC). Transactivation …

CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in …

N Gupta, CD Mohan, MK Shanmugam, YY Jung… - Environmental …, 2023 - Elsevier
Environmental factors such as exposure to ionizing radiations, certain environmental
pollutants, and toxic chemicals are considered as risk factors in the development of breast …

Brucein D imparts a growth inhibitory effect in multiple myeloma cells by abrogating the Akt‐driven signaling pathway

YY Jung, CD Mohan, S Rangappa, JY Um… - IUBMB …, 2023 - Wiley Online Library
The Akt signaling pathway is an oncogenic cascade activated in the bone marrow
microenvironment of multiple myeloma (MM) cells and contributes to their uncontrolled …