Small molecule based five-membered heterocycles: A view of liquid crystalline properties beyond the biological applications
Liquid crystal (LC) is an intermediate phase of matter with the physical attributes of liquid,
and a high-level of orientational order of solids. This property of LCs has been widely …
and a high-level of orientational order of solids. This property of LCs has been widely …
Crocetin imparts antiproliferative activity via inhibiting STAT3 signaling in hepatocellular carcinoma
STAT3 is a key oncogenic transcription factor, often overactivated in several human cancers
including hepatocellular carcinoma (HCC). STAT3 modulates the expression of genes that …
including hepatocellular carcinoma (HCC). STAT3 modulates the expression of genes that …
Novel 1, 3, 4-oxadiazole induces anticancer activity by targeting NF-κB in hepatocellular carcinoma cells
CD Mohan, NC Anilkumar, S Rangappa… - Frontiers in …, 2018 - frontiersin.org
Aberrant activation of NF-κB is linked with the progression of human malignancies including
hepatocellular carcinoma (HCC), and blockade of NF-κB signaling could be a potential …
hepatocellular carcinoma (HCC), and blockade of NF-κB signaling could be a potential …
Insights into adopted synthetic approaches for 1, 2, 4-oxadiazoles: A review
A five-membered heterocyclic compound known as 1, 2, 4-oxadiazole has one oxygen, two
carbon, and two nitrogen atoms within a ring. Numerous studies have shown that 1, 2, 4 …
carbon, and two nitrogen atoms within a ring. Numerous studies have shown that 1, 2, 4 …
Brucein D modulates MAPK signaling cascade to exert multi-faceted anti-neoplastic actions against breast cancer cells
CD Mohan, YY Liew, YY Jung, S Rangappa… - Biochimie, 2021 - Elsevier
Breast cancer is a prominent type of malignancy among women with a high rate of mortality.
A number of previous studies have demonstrated the anticancer potential of brucein D (BD) …
A number of previous studies have demonstrated the anticancer potential of brucein D (BD) …
[HTML][HTML] Nimbolide enhances the antitumor effect of docetaxel via abrogation of the NF-κB signaling pathway in prostate cancer preclinical models
J Zhang, YY Jung, CD Mohan, A Deivasigamani… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Prostate cancer is the second most frequent type of cancer that affects men. Docetaxel (DTX)
administration is the front-line therapy for patients with advanced prostate cancer and …
administration is the front-line therapy for patients with advanced prostate cancer and …
Co2(CO)8 as a Solid CO (g) Source for the Amino Carbonylation of (Hetero)aryl Halides with Highly Deactivated (Hetero)arylamines
Carbonylation of (hetero) aryl iodides/bromides with highly deactivated 2-aminopyridines
using Pd–Co (CO) 4 bimetallic catalysis is accomplished. The use of Co2 (CO) 8 as a solid …
using Pd–Co (CO) 4 bimetallic catalysis is accomplished. The use of Co2 (CO) 8 as a solid …
Euphorbiasteroid abrogates EGFR and Wnt/β-catenin signaling in non-small-cell lung cancer cells to impart anticancer activity
NY Kim, CD Mohan, A Chinnathambi, SA Alharbi… - Molecules, 2022 - mdpi.com
EGFR and Wnt/β-catenin signaling pathways play a prominent role in tumor progression in
various human cancers including non-small-cell lung carcinoma (NSCLC). Transactivation …
various human cancers including non-small-cell lung carcinoma (NSCLC). Transactivation …
CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in …
N Gupta, CD Mohan, MK Shanmugam, YY Jung… - Environmental …, 2023 - Elsevier
Environmental factors such as exposure to ionizing radiations, certain environmental
pollutants, and toxic chemicals are considered as risk factors in the development of breast …
pollutants, and toxic chemicals are considered as risk factors in the development of breast …
Brucein D imparts a growth inhibitory effect in multiple myeloma cells by abrogating the Akt‐driven signaling pathway
The Akt signaling pathway is an oncogenic cascade activated in the bone marrow
microenvironment of multiple myeloma (MM) cells and contributes to their uncontrolled …
microenvironment of multiple myeloma (MM) cells and contributes to their uncontrolled …