Targeting circular RNAs as a therapeutic approach: current strategies and challenges

AT He, J Liu, F Li, BB Yang - Signal transduction and targeted therapy, 2021 - nature.com
Significant progress has been made in circular RNA (circRNA) research in recent years.
Increasing evidence suggests that circRNAs play important roles in many cellular processes …

The potential of using blood circular RNA as liquid biopsy biomarker for human diseases

G Wen, T Zhou, W Gu - Protein & cell, 2021 - academic.oup.com
Circular RNA (circRNA) is a novel class of single-stranded RNAs with a closed loop
structure. The majority of circRNAs are formed by a back-splicing process in pre-mRNA …

Autophagy-associated circRNA circATG7 facilitates autophagy and promotes pancreatic cancer progression

Z He, K Cai, Z Zeng, S Lei, W Cao, X Li - Cell Death & Disease, 2022 - nature.com
Dysregulation of autophagy and circular RNAs (circRNAs) are involved in the pancreatic
cancer (PC) progression. However, the regulatory network between circRNAs, autophagy …

circEHBP1 promotes lymphangiogenesis and lymphatic metastasis of bladder cancer via miR-130a-3p/TGFβR1/VEGF-D signaling

J Zhu, Y Luo, Y Zhao, Y Kong, H Zheng, Y Li, B Gao… - Molecular Therapy, 2021 - cell.com
Lymphatic metastasis constitutes a leading cause of recurrence and mortality in bladder
cancer. Accumulating evidence indicates that lymphangiogenesis is indispensable to trigger …

Circular RNA circDtx1 regulates IRF3-mediated antiviral immune responses through suppression of miR-15a-5p-dependent TRIF downregulation in teleost fish

W Zheng, Q Chu, L Yang, L Sun, T Xu - PLoS pathogens, 2021 - journals.plos.org
Circular RNAs (circRNAs) represent a class of widespread and diverse covalently closed
circular endogenous RNAs that exert crucial functions in regulating gene expression in …

Translation and emerging functions of non‐coding RNAs in inflammation and immunity

E Della Bella, J Koch, K Baerenfaller - Allergy, 2022 - Wiley Online Library
Regulatory non‐coding RNAs (ncRNAs) including small non‐coding RNAs (sRNAs), long
non‐coding RNAs (lncRNAs), and circular RNAs (circRNAs) have gained considerable …

Circular RNA circPIKfyve acts as a sponge of miR-21-3p to enhance antiviral immunity through regulation of MAVS in teleost fish

H Su, Q Chu, W Zheng, R Chang, W Gao… - Journal of …, 2021 - Am Soc Microbiol
Circular RNAs (circRNAs) are a class of widespread and diverse covalently closed circular
endogenous RNAs that exert crucial functions in regulating gene expression in mammals …

Sensitive, reliable and robust circRNA detection from RNA-seq with CirComPara2

E Gaffo, A Buratin, A Dal Molin… - Briefings in …, 2022 - academic.oup.com
Circular RNAs (circRNAs) are a large class of covalently closed RNA molecules originating
by a process called back-splicing. CircRNAs are emerging as functional RNAs involved in …

CircRNA_0050463 promotes influenza A virus replication by sponging miR-33b-5p to regulate EEF1A1

N Shi, S Zhang, Y Guo, X Yu, W Zhao, M Zhang… - Veterinary …, 2021 - Elsevier
Circular RNAs (circRNAs), a new class of widely expressed endogenous regulatory RNAs,
are characterized by a covalently closed loop structure without a 5'cap or 3'tail. Increasing …

Lessons learnt from COVID-19: computational strategies for facing present and future pandemics

M Pavan, S Moro - International Journal of Molecular Sciences, 2023 - mdpi.com
Since its outbreak in December 2019, the COVID-19 pandemic has caused the death of
more than 6.5 million people around the world. The high transmissibility of its causative …