Smooth muscle cells provide crucial contractile functions in visceral, vascular, and lung
tissues. The contractile state of smooth muscle is largely determined by their electrical …

Voltage-gated Kv7 potassium channels, encoded by KCNQ genes, have major physiological
impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells. Cyclic …

Urinary bladder smooth muscle (UBSM), also known as detrusor smooth muscle, forms the
bladder wall and ultimately determines the two main attributes of the organ: urine storage …

Background: The Kv7 (KCNQ) subfamily of voltage-gated potassium channels consists of 5
members (Kv7. 1-5) each showing characteristic tissue distribution and physiological roles …

Retigabine (RTG; international nonproprietary name)/ezogabine (EZG; North American
adopted name), a first‐in‐class antiepileptic drug (AED) that reduces neuronal excitability …

Retigabine is a first in class anticonvulsant that has recently undergone clinical trials to test
its efficacy in epileptic patients. Retigabine's novel mechanism of action–activating Kv7 …

Background and Purpose The aim of the study was to determine whether KCNQ channels
are functionally expressed in bladder smooth muscle cells (SMC) and to investigate their …

Background and Purpose The KCNQ‐encoded voltage‐gated potassium channel family (Kv
7.1‐Kv 7.5) are established regulators of smooth muscle contractility, where Kv 7.4 and Kv …

ABSTRACT Voltage‐gated Kv7/KCNQ/M potassium channels play an essential role in the
control of membrane potential and neuronal excitability. Activation of the neuronal …

The highly structurally similar drugs flupirtine and retigabine have been regarded as safe
and effective for many years but lately they turned out to exert intolerable side effects. While …