Type I allergic hypersensitivity disorders (atopy) including asthma, atopic dermatitis, allergic
rhinitis, and food allergy are on the rise in developed and developing countries. Engineered …

Highlights•AIT modulates the response of the patient against allergen for long-term
periods.•The generation of Treg cells results in the development of peripheral tolerance to …

This study investigates the regulatory effect of plasmacytoid dendritic cells (pDC)/myeloid
dendritic cells (mDC) imbalance on balance of Th1/Th2 and Th17/Treg in primary immune …

Dendritic cells (DCs) play a central role in the maintenance of immune homeostasis, their
participation as professional antigen presenting cells is essential to the initiation of the …

A vaccine must be sufficiently stable and cause no discernible discomfort or organ damage
both during administration and at the injection site. To achieve these aims, the skin offers a …

Bronchiolitis obliterans (BO), is a chronic rejection phenotype characterized by chronic small
airway fibrous obliteration, hinders the patients who suffer from lung transplanting for …

Hepatic macrophages play pivotal roles in tolerance induction after liver transplantation (LT).
However, macrophages possess functional heterogeneities, and the protective role of M2c …

Abstract Background Dendritic cells (DCs) and regulatory T (Treg) cells are crucial for
inducing immune tolerance. However, the suppressive function of infused Treg cells and …

Iloprost, a stable prostaglandin I 2 (PGI 2) analog, can inhibit allergic inflammation in an
ovalbumin (OVA)-induced asthma model via inhibition of airway dendritic cell (DC) function …

T regulatory (Treg) cells have a key role in immune homeostasis and the pathogenesis of
chronic inflammatory and autoimmune diseases. CD69 is an early leukocyte activation …