DNA topoisomerases are enzymes that disentangle the topological problems that arise in
double-stranded DNA. Many of these can be solved by the generation of either single or …

Genotoxic DNA damaging agents may activate both membrane death receptors and the
endogenous mitochondrial damage pathway leading to cell death via apoptosis. Here …

Using homology searches, we identified a novel human inhibitor of apoptosis (IAP) gene.
This gene has two splicing variants that contain open reading frames of 298 and 280 amino …

Targeted and efficient delivery of therapeutics to tumor cells is one of the key issues in
cancer therapy. In the present work, we report a temperature and pH dual responsive core …

Type II DNA topoisomerases (EC 5.99. 1.3) are enzymes that catalyse topological changes
in DNA in an ATP dependent manner. Strand passage reactions involve passing one double …

We have identified a novel human gene, kiap (k idney i nhibitor of a poptosis p rotein) that
encodes a single BIR domain and a RING zinc finger domain. kiap has been assigned to the …

The phylogenetic antiquity of DNA topoisomerases indicates their vital function. Structure
and maintenance of genomic DNA depend on the activity of these enzymes, and without …

Doxorubicin is a widely used chemotherapeutic agent that causes dose-dependent
cardiotoxicity in a subset of treated patients, but the genetic determinants of this …

We have examined corticogenesis in mouse embryos lacking DNA topoisomerase IIβ (IIβ) in
the brain or in all tissues. The absence of IIβ, a type II DNA topoisomerase normally …

DNA topoisomerase II enzymes regulate essential cellular processes by altering the
topology of chromosomal DNA. These enzymes function by creating transient double …