Type 2 diabetes is characterized by insulin resistance in target tissues and hyperglycemia.
Catalpol is a natural product isolated from the root of Rehmannia glutinosa, which has been …

Endoplasmic reticulum (ER) stress generally occurs in secretory cell types. It has been
reported that Leydig cells, which produce testosterone in response to human chorionic …

Abstract Kv2. 1 as a voltage-gated potassium (Kv) channel subunit has a pivotal role in the
regulation of glucose-stimulated insulin secretion (GSIS) and pancreatic β-cell apoptosis …

Diabetic cognitive impairment (DCI) is a common diabetic complication characterized by
learning and memory deficits. In diabetic patients, hyperactivated hypothalamic-pituitary …

Liver function indicators are often impaired in patients with type 2 diabetes mellitus (T2DM),
who present higher concentrations of aspartate aminotransferase, alanine …

Netrin-1 is typically known as a neural guidance cue, which has been implicated in
pancreas development. Since regenerative, angiogenic and anti-inflammatory properties of …

The reduction of insulin resistance or improvement of insulin sensitivity is the most effective
treatment for type 2 diabetes (T2D). We previously reported that Nogo-B receptor (NGBR) …

Two new cytosporone derivatives (1 and 2) were isolated from the endophytic fungus
Phomopsis sp. PSU-H188 together with 19 known compounds. Their structures were …

Endoplasmic reticulum stress (ER stress) plays a main role in pancreatic β-cell dysfunction
and death because of intracellular Ca 2+ turbulence and inflammation activation. Although …

The extract of the Momordica charantia fruit (MCE) is recognized as an alternative treatment
for diabetes. The extract of Ligularia fischeri leaves (LFE) is traditionally used as a folk …