Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway
J Yan, C Wang, Y Jin, Q Meng, Q Liu, Z Liu, K Liu… - Pharmacological …, 2018 - Elsevier
Type 2 diabetes is characterized by insulin resistance in target tissues and hyperglycemia.
Catalpol is a natural product isolated from the root of Rehmannia glutinosa, which has been …
Catalpol is a natural product isolated from the root of Rehmannia glutinosa, which has been …
hCG-induced endoplasmic reticulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of …
Endoplasmic reticulum (ER) stress generally occurs in secretory cell types. It has been
reported that Leydig cells, which produce testosterone in response to human chorionic …
reported that Leydig cells, which produce testosterone in response to human chorionic …
SP6616 as a new Kv2. 1 channel inhibitor efficiently promotes β-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways
TT Zhou, LL Quan, LP Chen, T Du, KX Sun… - Cell death & …, 2016 - nature.com
Abstract Kv2. 1 as a voltage-gated potassium (Kv) channel subunit has a pivotal role in the
regulation of glucose-stimulated insulin secretion (GSIS) and pancreatic β-cell apoptosis …
regulation of glucose-stimulated insulin secretion (GSIS) and pancreatic β-cell apoptosis …
FX5, a non-steroidal glucocorticoid receptor antagonist, ameliorates diabetic cognitive impairment in mice
D Zhu, J Lu, R Xu, J Yang, X Meng… - Acta Pharmacologica …, 2022 - nature.com
Diabetic cognitive impairment (DCI) is a common diabetic complication characterized by
learning and memory deficits. In diabetic patients, hyperactivated hypothalamic-pituitary …
learning and memory deficits. In diabetic patients, hyperactivated hypothalamic-pituitary …
Phosphoethanolamine cytidylyltransferase ameliorates mitochondrial function and apoptosis in hepatocytes in T2DM in vitro
H Xu, W Li, L Huang, X He, B Xu, X He, W Chen… - Journal of Lipid …, 2023 - ASBMB
Liver function indicators are often impaired in patients with type 2 diabetes mellitus (T2DM),
who present higher concentrations of aspartate aminotransferase, alanine …
who present higher concentrations of aspartate aminotransferase, alanine …
Dual actions of Netrin-1 on islet insulin secretion and immune modulation
S Gao, X Zhang, Y Qin, S Xu, J Zhang, Z Wang… - Clinical …, 2016 - portlandpress.com
Netrin-1 is typically known as a neural guidance cue, which has been implicated in
pancreas development. Since regenerative, angiogenic and anti-inflammatory properties of …
pancreas development. Since regenerative, angiogenic and anti-inflammatory properties of …
NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity
Y Chen, W Hu, Q Li, S Zhao, D Zhao, S Zhang… - Journal of Biological …, 2021 - ASBMB
The reduction of insulin resistance or improvement of insulin sensitivity is the most effective
treatment for type 2 diabetes (T2D). We previously reported that Nogo-B receptor (NGBR) …
treatment for type 2 diabetes (T2D). We previously reported that Nogo-B receptor (NGBR) …
Cytosporone derivatives from the endophytic fungus Phomopsis sp. PSU-H188
T Kongprapan, X Xu, V Rukachaisirikul… - Phytochemistry …, 2017 - Elsevier
Two new cytosporone derivatives (1 and 2) were isolated from the endophytic fungus
Phomopsis sp. PSU-H188 together with 19 known compounds. Their structures were …
Phomopsis sp. PSU-H188 together with 19 known compounds. Their structures were …
Natural Product Luteolin Rescues THAP-Induced Pancreatic β-Cell Dysfunction through HNF4α Pathway
W Wu, S He, Y Shen, J Zhang, Y Wan… - The American Journal …, 2020 - World Scientific
Endoplasmic reticulum stress (ER stress) plays a main role in pancreatic β-cell dysfunction
and death because of intracellular Ca 2+ turbulence and inflammation activation. Although …
and death because of intracellular Ca 2+ turbulence and inflammation activation. Although …
Antihyperglycemic and Antilipidemic Effects of the Ethanol Extract Mixture of Ligularia fischeri and Momordica charantia in Type II Diabetes‐Mimicking Mice
HJ Baek, YJ Jeong, JE Kwon, JS Ra… - Evidence‐Based …, 2018 - Wiley Online Library
The extract of the Momordica charantia fruit (MCE) is recognized as an alternative treatment
for diabetes. The extract of Ligularia fischeri leaves (LFE) is traditionally used as a folk …
for diabetes. The extract of Ligularia fischeri leaves (LFE) is traditionally used as a folk …