Lysosomal storage disorders (LSDs) are a vast group of more than 50 clinically identified
metabolic diseases. They are singly rare, but they affect collectively 1 on 5,000 live births …

The combination of genetics and genomics in Parkinson´ s disease has recently begun to
unveil molecular mechanisms possibly underlying disease onset and progression. In …

Autophagic impairment was identified in many lysosomal storage diseases and adult
neurodegenerative diseases. It seems that this defect could be directly related to the …

We have shown in vivo and in vitro previously that psychosine causes dysfunction of
autophagy and the ubiquitin-proteasome system underlying the pathogenesis of globoid cell …

Lysosomal storage disorders (LSDs) result from an enzyme deficiency within lysosomes.
The systemic administration of the missing enzyme, however, is not effective in the case of …

Globoid cell leukodystrophy (GLD), also known as Krabbe disease, is a lysosomal storage
disorder causing extensive demyelination in the central and peripheral nervous systems …

Osteoporosis is a widely distributed disease that may cause complications such as
accelerated tooth movement, bone resorption, and tooth loss during orthodontic treatment …

Accumulating evidence advances the critical role of autophagy in brain pathology after
stroke. Investigations employing autophagy induction or inhibition using pharmacological …

Lithium promotes autophagy and has a neuroprotective effect on spinal cord injury (SCI);
however, the underlying mechanisms remain unclear. Therefore, in this study, we …

Polymeric nanoparticles (NPs) represent one of the most promising tools in nanomedicine
and have been extensively studied for the delivery of water-insoluble drugs. However, the …