Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Coronary artery disease is a major underlying etiology for heart failure. The role of coronary
microvascular disease, and endothelial dysfunction, in the pathophysiology of heart failure is …

This article reviews the involvement of the mitochondrial permeability transition pore in
necrotic and apoptotic cell death. The pore is formed from a complex of the voltage …

Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …

Calcium is thought to play an important role in regulating mitochondrial function. Evidence
suggests that an increase in mitochondrial calcium can augment ATP production by altering …

Reperfusion may induce additional cell death in patients with acute myocardial infarction
receiving primary angioplasty or thrombolysis. Altered intracellular Ca2+ handling was …

The regulation of mammalian myocardial carbohydrate metabolism is complex in that it is
linked to arterial substrate and hormone levels, coronary flow, inotropic state and the …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

The transporters regulating the uptake of glucose belong to the GLUT family17–19 and
constitute a system of stereospecific and saturable transport/countertransport. The isoform …

Cardiomyocytes are one of the most mitochondria-rich cell types in the body, with∼ 30–40%
of the cell volume being composed of mitochondria. Mitochondria are well established as …