Synthetic approaches towards alkaloids bearing α-tertiary amines

A Hager, N Vrielink, D Hager, J Lefranc… - Natural product …, 2016 - pubs.rsc.org
Covering: up to August 2015 Alkaloids account for some of the most beautiful and
biologically active natural products. Although they are usually classified along biosynthetic …

Cutting-edge and time-honored strategies for stereoselective construction of C–N bonds in total synthesis

AK Mailyan, JA Eickhoff, AS Minakova, Z Gu… - Chemical …, 2016 - ACS Publications
The main objective of this review is to provide a comprehensive survey of methods used for
stereoselective construction of carbon–nitrogen bonds during the total synthesis of nitrogen …

Total synthesis of complex alkaloids by nucleophilic addition to amides

T Sato, M Yoritate, H Tajima, N Chida - Organic & biomolecular …, 2018 - pubs.rsc.org
Nucleophilic addition to amides has been recognized as a promising transformation for total
synthesis of complex alkaloids. Amides can accept two different organometallic reagents …

Enantioselective synthesis of cyclic nitrones by chemoselective intramolecular allylic alkylation of oximes

T Sandmeier, EM Carreira - Angewandte Chemie International …, 2021 - Wiley Online Library
The enantio‐and chemoselective iridium‐catalyzed N‐allylation of oximes is described for
the first time. Intramolecular kinetic resolution provides access to cyclic nitrones and …

A global and local desymmetrization approach to the synthesis of steroidal alkaloids: stereocontrolled total synthesis of paspaline

RJ Sharpe, JS Johnson - Journal of the American Chemical …, 2015 - ACS Publications
A stereocontrolled total synthesis of the indole diterpenoid natural product paspaline is
described. Key steps include a highly diastereoselective enzymatic desymmetrization …

General One‐Pot Reductive gem‐Bis‐Alkylation of Tertiary Lactams/Amides: Rapid Construction of 1‐Azaspirocycles and Formal Total Synthesis of (±) …

KJ Xiao, JM Luo, XE Xia, Y Wang… - Chemistry–A European …, 2013 - Wiley Online Library
Amides are a class of highly stable and readily available compounds. The amide functional
group constitutes a class of powerful directing/activating and protecting group for C C bond …

Stereoselective formation of fused tricyclic amines from acyclic aldehydes by a cascade process involving condensation, cyclization, and dipolar cycloaddition

AJM Burrell, I Coldham, L Watson, N Oram… - The Journal of …, 2009 - ACS Publications
The preparation of tricyclic amines from acyclic precursors is described using a cascade of
tandem reactions involving condensation of an aldehyde with a primary amine, cyclization …

Recent progress in transition metal catalyzed cross coupling of nitroarenes

L Peng, Z Hu, Z Tang, Y Jiao, X Xu - Chinese Chemical Letters, 2019 - Elsevier
In this review, the recent development in transition metal catalyzed cross coupling of
nitroarenes was highlighted. Firstly, development of transition metal catalyzed cross …

Total Synthesis of (−)‐Histrionicotoxin through a Stereoselective Radical Translocation–Cyclization Reaction

M Sato, H Azuma, A Daigaku, S Sato… - Angewandte Chemie …, 2017 - Wiley Online Library
Abstract Stereoselective total syntheses of (−)‐histrionicotoxin and (−)‐histrionicotoxin 235A
are described. The 1‐azaspiro [5.5] undecane skeleton was constructed diastereoselectively …

Construction of Cyclic Nitrones Enabled by Photodriven and Gold-Catalyzed 1, 3-Azaprotio Transfer of Allenyloximes

Z Qi, S Wang - The Journal of Organic Chemistry, 2023 - ACS Publications
A protocol was developed to construct five-to seven-membered cyclic nitrones through the
gold-catalyzed 1, 3-azaprotio transfer of allenyloximes under photoirradiation. The …