The intestinal tract faces numerous challenges that require several layers of defence. The
tight epithelium forms a physical barrier that is further protected by a mucus layer, which …

The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

INTRODUCTION An intricate balance with our intestinal microbes is pivotal to human health.
A key interface of host-microbial interactions occurs in the mucus that covers the intestinal …

Membrane fusion triggered by Ca2+ is orchestrated by a conserved set of proteins to
mediate synaptic neurotransmitter release, mucin secretion and other regulated exocytic …

Current management of severe asthma relying either on guidelines (bulk approach) or on
disease phenotypes (stratified approach) did not improve the burden of the disease. Several …

Goblet cell metaplasia, a disabling hallmark of chronic lung disease, lacks curative
treatments at present. To identify novel therapeutic targets for goblet cell metaplasia, we …

Rationale: MUC5AC (mucin 5AC, oligomeric gel-forming) and MUC5B (mucin 5B,
oligomeric gel-forming) are the predominant secreted polymeric mucins in mammalian …

Agonist-mediated stimulated pathway of mucin and insulin release are biphasic in which
rapid fusion of pre-docked granules is followed by slow docking and fusion of granules from …

The calcium‐activated chloride channel (CaCC) TMEM16A enables chloride secretion
across several transporting epithelia, including in the airways. Additional roles for TMEM16A …

Toll-interacting protein (Tollip) is a negative regulator of the pro-inflammatory response to
viruses, including influenza A virus (IAV). Genetic variation of Tollip has been associated …