Pain is a manifestation of rheumatoid arthritis (RA) that is mediated by inflammatory and non-
inflammatory mechanisms and negatively affects quality of life. Recent findings from a Phase …

The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

Benzalkonium chloride (BAK), a quaternary ammonium compound widely used as
disinfecting agent as well as preservative in eye drops is known to induce toxic effects on the …

Two major factors contribute to the failure of axonal regrowth in the central nervous system
(CNS), namely, the neuronal intrinsic regenerative capacity and the extrinsic local inhibitory …

Recent evidence indicates that targeting IL-6 provides broad therapeutic approaches to
several diseases. In patients with cancer, autoimmune diseases, severe respiratory …

Uterine factor infertility was considered incurable until recently when we reported the first
successful live birth after uterus transplantation. However, risky donor surgery and …

Denervated skeletal muscular atrophy is primarily characterized by loss of muscle strength
and mass and an unideal functional recovery of the muscle after extended denervation. This …

Background: To verify the hypothesis that the nature of trigeminal neuralgia (TN) is an
ectopic impulse induced by sodium channel modulated by cytokines, we conducted an …

Background Large gap healing is a difficult issue in the recovery of peripheral nerve injury.
The present study provides in vivo trials of silicone rubber chambers filled with collagen …

One of the changes brought about by Wallerian degeneration distal to nerve injury is
disintegration of axonal mitochondria and consequent leakage of mitochondrial DNA …