Simple Summary Obesity has been linked to several common cancers including breast,
colorectal, esophageal, kidney, gallbladder, uterine, pancreatic, and liver cancer. Obesity …

Few metabolites can claim a more central and versatile role in cell metabolism than acetyl
coenzyme A (acetyl-CoA). Acetyl-CoA is produced during nutrient catabolism to fuel the …

TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated
their epithelial antiproliferative response and benefit from increased TGFβ expression and …

A common feature of cancer cells is their ability to rewire their metabolism to sustain the
production of ATP and macromolecules needed for cell growth, division and survival. In …

Focal adhesion kinase (FAK) is both a non-receptor tyrosine kinase and an adaptor protein
that primarily regulates adhesion signalling and cell migration, but FAK can also promote …

CD36 is a type 2 cell surface scavenger receptor widely expressed in many immune and
non-immune cells. It functions as both a signaling receptor responding to DAMPs and …

Obesity is associated with both increased cancer incidence and progression in multiple
tumour types, and is estimated to contribute to up to 20% of cancer-related deaths. These …

Rates of obesity and diabetes have increased significantly over the past decades and the
prevalence is expected to continue to rise further in the coming years. Many observations …

The bone is the third most common site of metastasis for a wide range of solid tumors
including lung, breast, prostate, colorectal, thyroid, gynecologic, and melanoma, with 70% of …

Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …