The burden of Hospital care-associated infections (HCAIs) is becoming a global concern.
This is compounded by the emergence of virulent and high-risk bacterial strains such as" …

Historically, many species of bacteria have been reported to produce viable, cell wall
deficient (CWD) variants. A variety of terms have been used to refer to CWD bacteria and a …

Abstract Machine learning applied to large compendia of transcriptomic data has enabled
the decomposition of bacterial transcriptomes to identify independently modulated sets of …

ABSTRACT β-Lactam antibiotics exploit the essentiality of the bacterial cell envelope by
perturbing the peptidoglycan layer, typically resulting in rapid lysis and death. Many Gram …

Background The prevalence of multidrug-resistant hypervirulent K. pneumoniae (MDR-
hvKP) has gradually increased. It poses a severe threat to human health. However …

Pseudomonas aeruginosa can survive in a myriad of environments, partially due to
modifications of its lipid A, the membrane anchor of lipopolysaccharide. We previously …

Mechanosensitive mechanisms are often used to sense damage to tissue structure,
stimulating matrix synthesis and repair. While this kind of mechanoregulatory process is well …

The rapid emergence of carbapenem-resistant Klebsiella pneumoniae (Kp) strains in
diverse environmental niches, even outside of the clinical setting, poses a challenge for the …

Characterizing the physiological response of bacterial cells to antibiotics is crucial for
designing diagnostic techniques, treatment choices, and drug development. While bacterial …

Despite the notable clinical impact, recent molecular epidemiology regarding third-
generation-cephalosporin-resistant (3GC-R) Klebsiella pneumoniae in the USA remains …