The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

Regulated cell death (RCD) relies on activation and recruitment of pore-forming proteins
(PFPs) that function as executioners of specific cell death pathways: apoptosis regulator …

In multicellular organisms the regulated cell death apoptosis is critically important for both
ontogeny and homeostasis. Mitochondria are indispensable for stress-induced apoptosis …

Mitochondria are cellular organelles with a major role in many cellular processes, including
not only energy production, metabolism, and calcium homeostasis but also regulated cell …

The localization of Bcl-2 family members at the mitochondrial outer membrane (MOM) is a
crucial step in the implementation of apoptosis. We review evidence showing the role of the …

BOK is a poorly understood member of the BCL-2 family of proteins that has been proposed
to function as a pro-apoptotic, BAX-like effector. However, the molecular mechanism and …

BCL-2 proteins regulate mitochondrial poration in apoptosis initiation. How the pore-forming
BCL-2 Effector BAK is activated remains incompletely understood mechanistically. Here we …

The pore‐forming BCL‐2 family proteins are effectors of mitochondrial poration in apoptosis
initiation. Two atypical effectors—BOK and truncated BID (tBID)—join the canonical effectors …

Apoptosis is a common cell death program that is important in human health and disease.
Signaling in apoptosis is largely driven through protein–protein interactions. The BCL-2 …

Cell death plays a pivotal role in the maintenance of tissue homeostasis. Key players in the
controlled induction of cell death are the Death Receptors (DR). CD95 is a prototypic DR …