Site differences, or systematic differences in feature distributions across multiple data-
acquisition sites, are a known source of heterogeneity that may adversely affect large-scale …

Diagnostic criteria used in autism research have undergone a shift towards the inclusion of a
larger population, paralleled by increasing, but variable, estimates of autism prevalence …

Single cell RNA-seq has revolutionized transcriptomics by providing cell type resolution for
differential gene expression and expression quantitative trait loci (eQTL) analyses. However …

Objective: A fine-tuned balance of glucocorticoid receptor (GR) activation is essential for
organ formation, with disturbances influencing many health outcomes. In utero …

Exposure to stressful life events increases the risk for psychiatric disorders. Mechanistic
insight into the genetic factors moderating the impact of stress can increase our …

Different psychiatric disorders as well as exposure to adverse life events have individually
been associated with multiple age-related diseases and mortality. Age acceleration in …

Background Identifying neurobiologically based transdiagnostic categories of depression
and psychosis may elucidate heterogeneity and provide better candidates for predictive …

Major depressive disorder (MDD) is a complex and heterogeneous psychiatric syndrome
with genetic and environmental influences. In addition to neuroanatomical and circuit-level …

Humanized mouse models can be used to explore human gene regulatory elements (REs),
which frequently lie in non-coding and less conserved genomic regions. Epigenetic …

Background Major depressive disorder represents (MDD) a major cause of disability and
disease burden. Beside antidepressant medication, psychotherapy is a key approach of …