Proteomics analyses have been exploited for the discovery of novel biomarkers for the early
recognition and prognostic stratification of cancer patients. These analyses have now been …

Matrix-assisted laser desorption/ionization mass spectrometry imaging is a technique for
direct analysis of tissue sections without the use of molecular tags or contrast agents. The …

The ideal bioanalytical method is one that would allow the researcher to carry out sensitive,
selective, reproducible, fast, and in situ chemical measurements of the composition and …

Applications of time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS) were
demonstrated, focusing on multivariate analysis (MVA) such as principal component …

X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry
(ToF-SIMS) are much used analytical techniques that provide information about the …

In the secondary ion mass spectrometry (SIMS) of organic substances, the molecular weight
of the intact ions currently detectable is at best only as high as 1000 Da, which for all …

Cancer research is one of the most promising application areas for the new technology of
MALDI tissue imaging. Cancerous tissue can easily be distinguished from healthy tissue by …

The total ion current chromatogram (TICC) obtained by liquid–chromatography-mass
spectrometry (LC–MS) is often extremely complex and 'noisy'in appearance, particularly …

The evaluation of proteins on biodevices, such as the distribution or orientation of
immobilized proteins, is one of the most important issues for the development of …

Abstract Pattern Recognition Entropy (PRE) is a summary statistic for comparing and
understanding spectra. Here we introduce the concept of the 'reordered spectrum'in the …