Locus control regions (LCRs) are defined by their ability, in transgenic assays, to direct high-
level, tissue-specific expression of linked genes at all sites of integration examined and at …

In higher eukaryotes, transcriptional enhancers play critical roles in the integration of cellular
signaling information, but apart from a few well‐studied model enhancers, we lack a general …

The intranuclear position of many genes has been correlated with their activity state,
suggesting that migration to functional subcompartments may influence gene expression …

In both plants1–3 and Drosophila melanogastei4, 5. expression from a transgenic locus may
be silenced when repeated trans-gene copies are arranged as a concatameric array. This …

To develop a method for targeting expression of genes to the full hematopoietic system, we
have used transgenic mice to explore the transcriptional regulation of the vav gene, which is …

The phenotype of individual hematopoietic cells, like all other differentiated mammalian
cells, is determined by selective transcription of a subset of the genes encoded within the …

To explore the mechanism by which enhancers maintain gene expression, we have
assessed the ability of an enhancer and derivative mutants to influence silencing and …

Transcriptional enhancers are traditionally considered to regulate the rate at which a linked
promoter transcribes mRNA, but recent experiments suggest a reevaluation of this model is …

What determines phenotype is one of the most fundamental questions in biology.
Historically, the search for answers had focused on genetic or environmental variants, but …

Revealing how transcriptional bursting kinetics are genomically encoded is challenging
because genome structures are stochastic at the organization level and are suggestively …