The natural history of cancers can be understood through the lens of evolution given that the
driving forces of cancer development are mutation and selection of fitter clones. Cancer …

Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is
fuelled by studies showing that ageing tissues are often riddled with clones of complex …

Genetic and epigenetic variation, together with transcriptional plasticity, contribute to
intratumour heterogeneity. The interplay of these biological processes and their respective …

A hallmark of cancer is the avoidance of immune destruction. This process has been
primarily investigated in locally advanced or metastatic cancer,–; however, much less is …

The dominant mutational signature in colorectal cancer genomes is C> T deamination
(COSMIC Signature 1) and, in a small subgroup, mismatch repair signature (COSMIC …

Non-genetic alterations can produce changes in a cell's phenotype. In cancer, these
phenomena can influence a cell's fitness by conferring access to heritable, beneficial …

In the past decade, remarkable progress in cancer medicine has been achieved by the
development of treatments that target DNA sequence variants. However, a purely genetic …

In this study, we explore the dynamic process of colorectal cancer progression, emphasizing
the evolution toward a more metastatic phenotype. The term" evolution" as used in this study …

Reprogramming energy production from mitochondrial respiration to glycolysis is now
considered a hallmark of cancer. When tumors grow beyond a certain size they give rise to …

Non-genetic mechanisms have recently emerged as important drivers of anticancer drug
resistance. Among these, the drug tolerant persister (DTP) cell phenotype is attracting more …