Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

3854 growth factors. The mitogen-activated protein kinases (MAPKs) play a major role in
mitogenic signaling, and the canonical Ras-Raf-MEK [MAPK and extracellular signal …

Helicobacter pylori (H. pylori) infection is considered a major risk factor for gastric cancer.
CagA behaves as a major bacterial oncoprotein playing a key role in H. pylori-induced …

Parathyroid hormone (PTH) suppresses Dickkopf 1 (Dkk1) expression in osteoblasts. To
determine whether this suppression is essential for PTH-mediated Wnt signaling and bone …

Objectives Available literature documents that ischemic stroke can disrupt the morphology
and function of mitochondria and that the latter in other disease models can be preserved by …

Objective Deregulation of the Wnt signalling pathway by mutations in the Apc or β-catenin
genes underlies colorectal carcinogenesis. As a result, β-catenin stabilises, translocates to …

The WNTS are an expansive family of glycoprotein signaling molecules known mostly for the
roles they play in embryonic development. WNT signaling first caught the attention of …

Background PARP inhibitors (PARPi) benefit only a fraction of breast cancer patients with
BRCA mutations, and their efficacy is even more limited in triple-negative breast cancer …

Wnt/β-catenin signalling plays essential roles during embryonic development and in adult
tissue homeostasis. Canonical signalling through Wnt secreted ligands relies on the control …

Let-7 miRNAs are involved in carcinogenesis and tumor progression through their roles in
maintaining differentiation and normal development. However, there is little research …