The extracellular signal-regulated kinases 1/2 (ERK) are central signaling components that
regulate stimulated cellular processes such as proliferation and differentiation. When …

Nuclear factor-κB (NF-κB) has been widely implicated in the development and progression
of cancer. In colorectal cancer (CRC), NF-κB has a key role in cancer-related processes …

Colorectal cancer (CRC) is the third most common malignancy and one of the leading
causes of cancer-related death among men worldwide. CRC is a multifactor digestive …

Extracellular signal-regulated kinase 5 (ERK5) belongs to the mitogen-activated protein
kinase (MAPK) family that consists of highly conserved enzymes expressed in all eukaryotic …

Mitogen-activated protein kinases (MAPKs) regulate diverse cellular processes including
proliferation, cell survival, differentiation, and apoptosis. While conventional MAPK …

Highlights•The present review highlights the emerging clinical relevance of MEK5/ERK5
signalling as a therapeutic target and prognostic factor in several top-leading diagnosed …

Abstract Background Catharanthus roseus (L.) G. Don consists of a range of dimeric indole
alkaloids with significant antitumor activities. These alkaloids have been found to possess …

Simple Summary Alterations of the MEK5/ERK5 signaling pathway have been described in
several tumors, and emerging data are trying to explain the complexity of ERK5-related …

Endometrial cancer (EC) is the most common type of gynecologic cancer in women of
developed countries. Despite surgery combined with chemo-/radiotherapy regimens, overall …

The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is frequently de-regulated in
human cancer. Melanoma in particular exhibits a high incidence of activating BRAFV600E/K …