Pioneer transcription factors have the intrinsic biochemical ability to scan partial DNA
sequence motifs that are exposed on the surface of a nucleosome and thus access silent …

Pioneer transcription factors are able to bind a partially exposed motif on the surface of a
nucleosome, enabling the proteins to target sites in silent regions of chromatin that have …

Eukaryotic genomes are organized into chromatin domains. The molecular mechanisms
driving the formation of these domains are difficult to dissect in vivo and remain poorly …

Abstract 'Pioneer'transcription factors are required for stem-cell pluripotency, cell
differentiation and cell reprogramming,. Pioneer factors can bind nucleosomal DNA to …

Fate-changing transcription factors (TFs) scan chromatin to initiate new genetic programs
during cell differentiation and reprogramming. Yet the protein structure domains that allow …

The origin recognition complex (ORC) is essential for initiation of eukaryotic chromosome
replication as it loads the replicative helicase—the minichromosome maintenance (MCM) …

Enzymatic probes of chromatin structure reveal accessible versus inaccessible chromatin
states, while super-resolution microscopy reveals a continuum of chromatin compaction …

During cellular reprogramming, the pioneer transcription factor GATA3 binds chromatin, and
in a context-dependent manner directs local chromatin remodeling and enhancer formation …

Gene regulation in eukaryotes requires the controlled access of sequence-specific
transcription factors (TFs) to their sites in a chromatin landscape dominated by …

Pioneer transcription factors (pTFs) bind to target sites within compact chromatin, initiating
chromatin remodeling and controlling the recruitment of downstream factors. The …