Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two nuclear
receptors that are well-known for their roles in xenobiotic detoxification by regulating the …

Coregulator recruitment to nuclear receptors (NRs) and other transcription factors is
essential for proper metabolic gene regulation, with coactivators enhancing and …

The constitutive androstane receptor (CAR), a member of the nuclear receptor superfamily,
is a well-known xenosensor that regulates hepatic drug metabolism and detoxification. CAR …

Background Pregnane X receptor (PXR), which is a member of the nuclear receptor protein
family (nuclear receptor subfamily 1 group I member 2 [NR 1I2]), mediates the drug …

The constitutive androstane receptor (CAR) is initially defined as a xenobiotic nuclear
receptor that protects the liver from injury. Detoxification of damaging chemicals is achieved …

Background The constitutive androstane receptor (CAR) is a member of the nuclear receptor
superfamily (subfamily 1, group I, member 3, also known as NR1I3) that is almost exclusively …

Introduction: Protein-protein interaction and signaling crosstalk contribute to the regulation of
pregnane X receptor (PXR) and constitutive androstane receptor (CAR) and broaden their …

The constitutive androstane receptor (CAR; NR1I3) has emerged as one of the main drug-
and xenobiotic-sensitive transcriptional regulators. It has a major effect on the expression of …

Background Liver regeneration following partial hepatectomy (PHx) is a complicated
process involving multiple organs and several types of signaling networks. The bile acid …

Humans are exposed to different kinds of environmental contaminants or drugs throughout
their lifetimes. The widespread presence of these compounds has raised concerns about the …