Hormonal contraception and HIV-1 acquisition: biological mechanisms
Access to effective affordable contraception is critical for individual and public health. A wide
range of hormonal contraceptives (HCs), which differ in composition, concentration of the …
range of hormonal contraceptives (HCs), which differ in composition, concentration of the …
The initial interplay between HIV and mucosal innate immunity
V Caputo, M Libera, S Sisti, B Giuliani… - Frontiers in …, 2023 - frontiersin.org
Human Immunodeficiency Virus (HIV) is still one of the major global health issues, and
despite significant efforts that have been put into studying the pathogenesis of HIV infection …
despite significant efforts that have been put into studying the pathogenesis of HIV infection …
Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir
The latent reservoir is a major barrier to HIV cure. As latently infected cells cannot be
phenotyped directly, the features of the in vivo reservoir have remained elusive. Here, we …
phenotyped directly, the features of the in vivo reservoir have remained elusive. Here, we …
[HTML][HTML] Attacking latent HIV with convertibleCAR-T cells, a highly adaptable killing platform
Current approaches to reducing the latent HIV reservoir entail first reactivating virus-
containing cells to become visible to the immune system. A critical second step is killing …
containing cells to become visible to the immune system. A critical second step is killing …
Mechanisms of HIV-1 cell-to-cell transmission and the establishment of the latent reservoir
KD Pedro, AJ Henderson, LM Agosto - Virus research, 2019 - Elsevier
HIV-1 spreads through both the release of cell-free particles and by cell-to-cell transmission.
Mounting evidence indicates that cell-to-cell transmission is more efficient than cell-free …
Mounting evidence indicates that cell-to-cell transmission is more efficient than cell-free …
HIV efficiently infects T cells from the endometrium and remodels them to promote systemic viral spread
The female reproductive tract (FRT) is the most common site of infection during HIV
transmission to women, but viral remodeling complicates characterization of cells targeted …
transmission to women, but viral remodeling complicates characterization of cells targeted …
Mucosa: key interactions determining sexual transmission of the HIV infection
In the context of HIV sexual transmission at the genital mucosa, initial interactions between
the virus and the mucosal immunity determine the outcome of the exposure. Hence, these …
the virus and the mucosal immunity determine the outcome of the exposure. Hence, these …
All-round manipulation of the actin cytoskeleton by HIV
A Ospina Stella, S Turville - Viruses, 2018 - mdpi.com
While significant progress has been made in terms of human immunodeficiency virus (HIV)
therapy, treatment does not represent a cure and remains inaccessible to many people …
therapy, treatment does not represent a cure and remains inaccessible to many people …
Evidence of the extrahepatic replication of Hepatitis E virus in human endometrial stromal cells
Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide. The
tropism of HEV is not restricted to the liver, and the virus replicates in other organs. Not all …
tropism of HEV is not restricted to the liver, and the virus replicates in other organs. Not all …
The role of defensins in HIV pathogenesis
BT Pace, AA Lackner, E Porter… - Mediators of …, 2017 - Wiley Online Library
Profound loss of CD4+ T cells, progressive impairment of the immune system, inflammation,
and sustained immune activation are the characteristics of human immunodeficiency virus‐1 …
and sustained immune activation are the characteristics of human immunodeficiency virus‐1 …